Search Results
Overview
| Uniprot ID | P51583 |
|---|---|
| Protein Name | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase |
| Gene Name | Paics |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 235 | KQSYRDLKEVTPEGL |
| 247 | EGLQMVKKNFEWVAD |
| 304 | LRVTSAHKGPDETLR |
| 36 | GRVLLQSKDQITAGN |
| 47 | TAGNAARKNHLEGKA |
Function
Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway
Protein Sequence
10
MATAEVLNIG
20
RKLYEGKTKE
30
VYELLDSPGR
40
VLLQSKDQIT
50
AGNAARKNHL
60
EGKAAISNKI
70
TSCIFQLLQE
80
AGIKTAFTKK
90
CGETAFIAPQ
100
CEMIPIEWVC
110
RRIATGSFLK
120
RNPGVKEGYR
130
FYPPKVEMFF
140
KDDANNDPQW
150
SEEQLIAAKF
160
CFAGLVIGQT
170
EVDIMSHATQ
180
AIFEILEKSW
190
LPQNCTLVDM
200
KIEFGVDVTT
210
KEIVLADVID
220
NDSWRLWPSG
230
DRSQQKDKQS
240
YRDLKEVTPE
250
GLQMVKKNFE
260
WVADRVELLL
270
KSNSQCRVVV
280
LMGSTSDLGH
290
CEKIKKACGN
300
FGIPCELRVT
310
SAHKGPDETL
320
RIKAEYEGDG
330
IPTVFVAVAG
340
RSNGLGPVMS
350
GNTAYPVISC
360
PPITADWGAQ
370
DVWSSLRLPS
380
GIGCSTILSP
390
EGSAQFAAQI
400
FGLNNHLVWA
410
KLRASKLNTW
420
ISLKQADKKI
RECNL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Biological Process | GO:0000082 | G1/S transition of mitotic cell cycle |
| Biological Process | GO:0006177 | GMP biosynthetic process |
| Biological Process | GO:0009113 | purine nucleobase biosynthetic process |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004638 | phosphoribosylaminoimidazole carboxylase activity |
| Molecular Function | GO:0004639 | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| Biological Process | GO:0044208 | 'de novo' AMP biosynthetic process |
| Biological Process | GO:0006189 | 'de novo' IMP biosynthetic process |
| Biological Process | GO:0097294 | 'de novo' XMP biosynthetic process |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.