Search Results

Overview

Uniprot IDP51610
Protein NameHost cell factor 1
Gene NameHCFC1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1163 LEAAQGSKSQCQTRQ
1217 QLAPLSSKVRLSSPS
1808 PSKAPMKKENQWFDV
1863 LQPGTAYKFRVAGIN
2005 RWLQETSKDSSGTKP
2015 SGTKPANKRPMSSPE
2024 PMSSPEMKSAPKKSK
345 SGRDGYRKAWNNQVC
813 SGTGAPAKIITAVPK
820 KIITAVPKIATGHGQ
836 GVTQVVLKGAPGQPG

Function

Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity)

Protein Sequence

10 MASAVSPANL 20 PAVLLQPRWK 30 RVVGWSGPVP 40 RPRHGHRAVA 50 IKELIVVFGG 60 GNEGIVDELH 70 VYNTATNQWF 80 IPAVRGDIPP 90 GCAAYGFVCD 100 GTRLLVFGGM 110 VEYGKYSNDL 120 YELQASRWEW 130 KRLKAKTPKN 140 GPPPCPRLGH 150 SFSLVGNKCY 160 LFGGLANDSE 170 DPKNNIPRYL 180 NDLYILELRP 190 GSGVVAWDIP 200 ITYGVLPPPR 210 ESHTAVVYTE 220 KDNKKSKLVI 230 YGGMSGCRLG 240 DLWTLDIDTL 250 TWNKPSLSGV 260 APLPRSLHSA 270 TTIGNKMYVF 280 GGWVPLVMDD 290 VKVATHEKEW 300 KCTNTLACLN 310 LDTMAWETIL 320 MDTLEDNIPR 330 ARAGHCAVAI 340 NTRLYIWSGR 350 DGYRKAWNNQ 360 VCCKDLWYLE 370 TEKPPPPARV 380 QLVRANTNSL 390 EVSWGAVATA 400 DSYLLQLQKY 410 DIPATAATAT 420 SPTPNPVPSV 430 PANPPKSPAP 440 AAAAPAVQPL 450 TQVGITLLPQ 460 AAPAPPTTTT 470 IQVLPTVPGS 480 SISVPTAART 490 QGVPAVLKVT 500 GPQATTGTPL 510 VTMRPASQAG 520 KAPVTVTSLP 530 AGVRMVVPTQ 540 SAQGTVIGSS 550 PQMSGMAALA 560 AAAAATQKIP 570 PSSAPTVLSV 580 PAGTTIVKTM 590 AVTPGTTTLP 600 ATVKVASSPV 610 MVSNPATRML 620 KTAAAQVGTS 630 VSSATNTSTR 640 PIITVHKSGT 650 VTVAQQAQVV 660 TTVVGGVTKT 670 ITLVKSPISV 680 PGGSALISNL 690 GKVMSVVQTK 700 PVQTSAVTGQ 710 ASTGPVTQII 720 QTKGPLPAGT 730 ILKLVTSADG 740 KPTTIITTTQ 750 ASGAGTKPTI 760 LGISSVSPST 770 TKPGTTTIIK 780 TIPMSAIITQ 790 AGATGVTSSP 800 GIKSPITIIT 810 TKVMTSGTGA 820 PAKIITAVPK 830 IATGHGQQGV 840 TQVVLKGAPG 850 QPGTILRTVP 860 MGGVRLVTPV 870 TVSAVKPAVT 880 TLVVKGTTGV 890 TTLGTVTGTV 900 STSLAGAGGH 910 STSASLATPI 920 TTLGTIATLS 930 SQVINPTAIT 940 VSAAQTTLTA 950 AGGLTTPTIT 960 MQPVSQPTQV 970 TLITAPSGVE 980 AQPVHDLPVS 990 ILASPTTEQP 1000 TATVTIADSG 1010 QGDVQPGTVT 1020 LVCSNPPCET 1030 HETGTTNTAT 1040 TTVVANLGGH 1050 PQPTQVQFVC 1060 DRQEAAASLV 1070 TSTVGQQNGS 1080 VVRVCSNPPC 1090 ETHETGTTNT 1100 ATTATSNMAG 1110 QHGCSNPPCE 1120 THETGTTNTA 1130 TTAMSSVGAN 1140 HQRDARRACA 1150 AGTPAVIRIS 1160 VATGALEAAQ 1170 GSKSQCQTRQ 1180 TSATSTTMTV 1190 MATGAPCSAG 1200 PLLGPSMARE 1210 PGGRSPAFVQ 1220 LAPLSSKVRL 1230 SSPSIKDLPA 1240 GRHSHAVSTA 1250 AMTRSSVGAG 1260 EPRMAPVCES 1270 LQGGSPSTTV 1280 TVTALEALLC 1290 PSATVTQVCS 1300 NPPCETHETG 1310 TTNTATTSNA 1320 GSAQRVCSNP 1330 PCETHETGTT 1340 HTATTATSNG 1350 GTGQPEGGQQ 1360 PPAGRPCETH 1370 QTTSTGTTMS 1380 VSVGALLPDA 1390 TSSHRTVESG 1400 LEVAAAPSVT 1410 PQAGTALLAP 1420 FPTQRVCSNP 1430 PCETHETGTT 1440 HTATTVTSNM 1450 SSNQDPPPAA 1460 SDQGEVESTQ 1470 GDSVNITSSS 1480 AITTTVSSTL 1490 TRAVTTVTQS 1500 TPVPGPSVPP 1510 PEELQVSPGP 1520 RQQLPPRQLL 1530 QSASTALMGE 1540 SAEVLSASQT 1550 PELPAAVDLS 1560 STGEPSSGQE 1570 SAGSAVVATV 1580 VVQPPPPTQS 1590 EVDQLSLPQE 1600 LMAEAQAGTT 1610 TLMVTGLTPE 1620 ELAVTAAAEA 1630 AAQAAATEEA 1640 QALAIQAVLQ 1650 AAQQAVMGTG 1660 EPMDTSEAAA 1670 TVTQAELGHL 1680 SAEGQEGQAT 1690 TIPIVLTQQE 1700 LAALVQQQQL 1710 QEAQAQQQHH 1720 HLPTEALAPA 1730 DSLNDPAIES 1740 NCLNELAGTV 1750 PSTVALLPST 1760 ATESLAPSNT 1770 FVAPQPVVVA 1780 SPAKLQAAAT 1790 LTEVANGIES 1800 LGVKPDLPPP 1810 PSKAPMKKEN 1820 QWFDVGVIKG 1830 TNVMVTHYFL 1840 PPDDAVPSDD 1850 DLGTVPDYNQ 1860 LKKQELQPGT 1870 AYKFRVAGIN 1880 ACGRGPFSEI 1890 SAFKTCLPGF 1900 PGAPCAIKIS 1910 KSPDGAHLTW 1920 EPPSVTSGKI 1930 IEYSVYLAIQ 1940 SSQAGGELKS 1950 STPAQLAFMR 1960 VYCGPSPSCL 1970 VQSSSLSNAH 1980 IDYTTKPAII 1990 FRIAARNEKG 2000 YGPATQVRWL 2010 QETSKDSSGT 2020 KPANKRPMSS 2030 PEMKSAPKKS KADGQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0000123 histone acetyltransferase complex
Cellular Component GO:0035097 histone methyltransferase complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0071339 MLL1 complex
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0048188 Set1C/COMPASS complex
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0031490 chromatin DNA binding
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045787 positive regulation of cell cycle
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0050821 protein stabilization
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0043254 regulation of protein-containing complex assembly
Biological Process GO:0019046 release from viral latency

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[9] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.