Search Results
Overview
| Uniprot ID | P51648 |
|---|---|
| Protein Name | Aldehyde dehydrogenase family 3 member A2 |
| Gene Name | ALDH3A2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 218 | KSPCYIDKDCDLDIV |
| 274 | EFYGENIKESPDYER |
| 324 | VLTDVDPKTKVMQEE |
| 357 | NFINEREKPLALYVF |
| 369 | YVFSHNHKLIKRMID |
Function
Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:18035827, PubMed:18182499, PubMed:22633490, PubMed:25047030, PubMed:9133646, PubMed:9662422). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490)
Protein Sequence
10
MELEVRRVRQ
20
AFLSGRSRPL
30
RFRLQQLEAL
40
RRMVQEREKD
50
ILTAIAADLC
60
KSEFNVYSQE
70
VITVLGEIDF
80
MLENLPEWVT
90
AKPVKKNVLT
100
MLDEAYIQPQ
110
PLGVVLIIGA
120
WNYPFVLTIQ
130
PLIGAIAAGN
140
AVIIKPSELS
150
ENTAKILAKL
160
LPQYLDQDLY
170
IVINGGVEET
180
TELLKQRFDH
190
IFYTGNTAVG
200
KIVMEAAAKH
210
LTPVTLELGG
220
KSPCYIDKDC
230
DLDIVCRRIT
240
WGKYMNCGQT
250
CIAPDYILCE
260
ASLQNQIVWK
270
IKETVKEFYG
280
ENIKESPDYE
290
RIINLRHFKR
300
ILSLLEGQKI
310
AFGGETDEAT
320
RYIAPTVLTD
330
VDPKTKVMQE
340
EIFGPILPIV
350
PVKNVDEAIN
360
FINEREKPLA
370
LYVFSHNHKL
380
IKRMIDETSS
390
GGVTGNDVIM
400
HFTLNSFPFG
410
GVGSSGMGAY
420
HGKHSFDTFS
430
HQRPCLLKSL
440
KREGANKLRY
450
PPNSQSKVDW
460
GKFFLLKRFN
470
KEKLGLLLLT
480
FLGIVAAVLV
KAEYY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0008544 | epidermis development |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0046458 | hexadecanal metabolic process |
| Biological Process | GO:0007422 | peripheral nervous system development |
| Biological Process | GO:0033306 | phytol metabolic process |
| Biological Process | GO:0006714 | sesquiterpenoid metabolic process |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005778 | peroxisomal membrane |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity |
| Molecular Function | GO:0004029 | aldehyde dehydrogenase (NAD+) activity |
| Molecular Function | GO:0120553 | farnesal dehydrogenase (NAD+) activity |
| Molecular Function | GO:0050061 | long-chain fatty aldehyde dehydrogenase (NAD+) activity |
| Molecular Function | GO:0046577 | long-chain-alcohol oxidase activity |
| Molecular Function | GO:0052814 | medium-chain fatty aldehyde dehydrogenase (NAD+) activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0006081 | aldehyde metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.