Search Results
Overview
| Uniprot ID | P51649 |
|---|---|
| Protein Name | Succinate-semialdehyde dehydrogenase, mitochondrial |
| Gene Name | ALDH5A1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 118 | RWREVSAKERSSLLR |
| 126 | ERSSLLRKWYNLMIQ |
| 135 | YNLMIQNKDDLARII |
| 184 | DIIHTPAKDRRALVL |
| 262 | NVIPCSRKNAKEVGE |
| 265 | PCSRKNAKEVGEAIC |
| 290 | TGSTTTGKILLHHAA |
| 301 | HHAANSVKRVSMELG |
| 358 | GIHDAFVKAFAEAMK |
| 365 | KAFAEAMKKNLRVGN |
| 387 | QGPLINEKAVEKVEK |
| 391 | INEKAVEKVEKQVND |
| 394 | KAVEKVEKQVNDAVS |
| 402 | QVNDAVSKGATVVTG |
| 411 | ATVVTGGKRHQLGKN |
Function
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
Protein Sequence
10
MATCIWLRSC
20
GARRLGSTFP
30
GCRLRPRAGG
40
LVPASGPAPG
50
PAQLRCYAGR
60
LAGLSAALLR
70
TDSFVGGRWL
80
PAAATFPVQD
90
PASGAALGMV
100
ADCGVREARA
110
AVRAAYEAFC
120
RWREVSAKER
130
SSLLRKWYNL
140
MIQNKDDLAR
150
IITAESGKPL
160
KEAHGEILYS
170
AFFLEWFSEE
180
ARRVYGDIIH
190
TPAKDRRALV
200
LKQPIGVAAV
210
ITPWNFPSAM
220
ITRKVGAALA
230
AGCTVVVKPA
240
EDTPFSALAL
250
AELASQAGIP
260
SGVYNVIPCS
270
RKNAKEVGEA
280
ICTDPLVSKI
290
SFTGSTTTGK
300
ILLHHAANSV
310
KRVSMELGGL
320
APFIVFDSAN
330
VDQAVAGAMA
340
SKFRNTGQTC
350
VCSNQFLVQR
360
GIHDAFVKAF
370
AEAMKKNLRV
380
GNGFEEGTTQ
390
GPLINEKAVE
400
KVEKQVNDAV
410
SKGATVVTGG
420
KRHQLGKNFF
430
EPTLLCNVTQ
440
DMLCTHEETF
450
GPLAPVIKFD
460
TEEEAIAIAN
470
AADVGLAGYF
480
YSQDPAQIWR
490
VAEQLEVGMV
500
GVNEGLISSV
510
ECPFGGVKQS
520
GLGREGSKYG
530
IDEYLELKYV
CYGGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004777 | succinate-semialdehyde dehydrogenase (NAD+) activity |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0009450 | gamma-aminobutyric acid catabolic process |
| Biological Process | GO:0006536 | glutamate metabolic process |
| Biological Process | GO:0006105 | succinate metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.