Search Results
Overview
| Uniprot ID | P51650 |
|---|---|
| Protein Name | Succinate-semialdehyde dehydrogenase, mitochondrial |
| Gene Name | Aldh5a1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 172 | DIIYTSAKDKRGLVL |
| 253 | PCSRTKAKEVGEVLC |
| 353 | TKFAEAMKKSLRVGN |
| 382 | KAVEKVEKHVNDAVA |
| 390 | HVNDAVAKGATVVTG |
| 399 | ATVVTGGKRHQSGGN |
Function
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
Protein Sequence
10
MATCFLLRNF
20
CAARPALRPP
30
GRLLREPAGA
40
QRRSYVGGPA
50
DLHADLLRGD
60
SFVGGRWLPT
70
PATFPVYDPA
80
SGAKLGTVAD
90
CGVPEARAAV
100
RAAYDAFSSW
110
KEISVKERSS
120
LLRKWYDLMI
130
QNKDELAKII
140
TAESGKPLKE
150
AQGEILYSAF
160
FLEWFSEEAR
170
RVYGDIIYTS
180
AKDKRGLVLK
190
QPVGVASIIT
200
PWNFPSAMIT
210
RKVGAALAAG
220
CTVVVKPAED
230
TPYSALALAQ
240
LANQAGIPPG
250
VYNVIPCSRT
260
KAKEVGEVLC
270
TDPLVSKISF
280
TGSTATGKIL
290
LHHAANSVKR
300
VSMELGGLAP
310
FIVFDSANVD
320
QAVAGAMASK
330
FRNAGQTCVC
340
SNRFLVQRGI
350
HDSFVTKFAE
360
AMKKSLRVGN
370
GFEEGTTQGP
380
LINEKAVEKV
390
EKHVNDAVAK
400
GATVVTGGKR
410
HQSGGNFFEP
420
TLLSNVTRDM
430
LCITEETFGP
440
VAPVIKFDKE
450
EEAVAIANAA
460
DVGLAGYFYS
470
QDPAQIWRVA
480
EQLEVGMVGV
490
NEGLISSVEC
500
PFGGVKQSGL
510
GREGSKYGID
520
EYLEVKYVCY
GGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0031406 | carboxylic acid binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0004777 | succinate-semialdehyde dehydrogenase (NAD+) activity |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0009450 | gamma-aminobutyric acid catabolic process |
| Biological Process | GO:0009448 | gamma-aminobutyric acid metabolic process |
| Biological Process | GO:0006536 | glutamate metabolic process |
| Biological Process | GO:0009791 | post-embryonic development |
| Biological Process | GO:0006105 | succinate metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.