Overview
| Uniprot ID | P51654 |
|---|
| Protein Name | Glypican-3 |
|---|
| Gene Name | GPC3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 374 |
FIDKKVLKVAHVEHE |
Function
Cell surface proteoglycan (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity)
Protein Sequence
10
MAGTVRTACL
20
VVAMLLSLDF
30
PGQAQPPPPP
40
PDATCHQVRS
50
FFQRLQPGLK
60
WVPETPVPGS
70
DLQVCLPKGP
80
TCCSRKMEEK
90
YQLTARLNME
100
QLLQSASMEL
110
KFLIIQNAAV
120
FQEAFEIVVR
130
HAKNYTNAMF
140
KNNYPSLTPQ
150
AFEFVGEFFT
160
DVSLYILGSD
170
INVDDMVNEL
180
FDSLFPVIYT
190
QLMNPGLPDS
200
ALDINECLRG
210
ARRDLKVFGN
220
FPKLIMTQVS
230
KSLQVTRIFL
240
QALNLGIEVI
250
NTTDHLKFSK
260
DCGRMLTRMW
270
YCSYCQGLMM
280
VKPCGGYCNV
290
VMQGCMAGVV
300
EIDKYWREYI
310
LSLEELVNGM
320
YRIYDMENVL
330
LGLFSTIHDS
340
IQYVQKNAGK
350
LTTTIGKLCA
360
HSQQRQYRSA
370
YYPEDLFIDK
380
KVLKVAHVEH
390
EETLSSRRRE
400
LIQKLKSFIS
410
FYSALPGYIC
420
SHSPVAENDT
430
LCWNGQELVE
440
RYSQKAARNG
450
MKNQFNLHEL
460
KMKGPEPVVS
470
QIIDKLKHIN
480
QLLRTMSMPK
490
GRVLDKNLDE
500
EGFESGDCGD
510
DEDECIGGSG
520
DGMIKVKNQL
530
RFLAELAYDL
540
DVDDAPGNSQ
550
QATPKDNEIS
560
TFHNLGNVHS
570
PLKLLTSMAI
580
SVVCFFFLVH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0005788 |
endoplasmic reticulum lumen |
| Cellular Component |
GO:0031012 |
extracellular matrix |
| Cellular Component |
GO:0005796 |
Golgi lumen |
| Cellular Component |
GO:0043202 |
lysosomal lumen |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0098552 |
side of membrane |
| Molecular Function |
GO:0060422 |
peptidyl-dipeptidase inhibitor activity |
| Biological Process |
GO:0009653 |
anatomical structure morphogenesis |
| Biological Process |
GO:0016477 |
cell migration |
| Biological Process |
GO:0042074 |
cell migration involved in gastrulation |
| Biological Process |
GO:0072111 |
cell proliferation involved in kidney development |
| Biological Process |
GO:0060976 |
coronary vasculature development |
| Biological Process |
GO:0072138 |
mesenchymal cell proliferation involved in ureteric bud development |
| Biological Process |
GO:0072180 |
mesonephric duct morphogenesis |
| Biological Process |
GO:0045879 |
negative regulation of smoothened signaling pathway |
| Biological Process |
GO:0090263 |
positive regulation of canonical Wnt signaling pathway |
| Biological Process |
GO:0045807 |
positive regulation of endocytosis |
| Biological Process |
GO:0045732 |
positive regulation of protein catabolic process |
| Biological Process |
GO:0060828 |
regulation of canonical Wnt signaling pathway |
| Biological Process |
GO:2000050 |
regulation of non-canonical Wnt signaling pathway |
| Biological Process |
GO:1905475 |
regulation of protein localization to membrane |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.