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Overview

Uniprot IDP51665
Protein Name26S proteasome non-ATPase regulatory subunit 7
Gene NamePSMD7
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
100 GWYHTGPKLHKNDIA
180 EHLLRDIKDTTVGTL
199 TNQVHGLKGLNSKLL
204 GLKGLNSKLLDIRSY
279 LHNLINNKIANRDAE
45 VLLGSWQKKVLDVSN

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair

Protein Sequence

10 MPELAVQKVV 20 VHPLVLLSVV 30 DHFNRIGKVG 40 NQKRVVGVLL 50 GSWQKKVLDV 60 SNSFAVPFDE 70 DDKDDSVWFL 80 DHDYLENMYG 90 MFKKVNARER 100 IVGWYHTGPK 110 LHKNDIAINE 120 LMKRYCPNSV 130 LVIIDVKPKD 140 LGLPTEAYIS 150 VEEVHDDGTP 160 TSKTFEHVTS 170 EIGAEEAEEV 180 GVEHLLRDIK 190 DTTVGTLSQR 200 ITNQVHGLKG 210 LNSKLLDIRS 220 YLEKVATGKL 230 PINHQIIYQL 240 QDVFNLLPDV 250 SLQEFVKAFY 260 LKTNDQMVVV 270 YLASLIRSVV 280 ALHNLINNKI 290 ANRDAEKKEG 300 QEKEESKKDR 310 KEDKEKDKDK 320 EKSDVKKEEK KEKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Biological Process GO:0071357 cellular response to type I interferon
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0006979 response to oxidative stress
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000502 proteasome complex
Cellular Component GO:0005838 proteasome regulatory particle
Cellular Component GO:0034774 secretory granule lumen
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0042803 protein homodimerization activity

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.