Search Results
Overview
| Uniprot ID | P51667 |
|---|---|
| Protein Name | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform |
| Gene Name | Myl2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 111 | KVFDPEGKGSLKADY |
| 115 | PEGKGSLKADYVREM |
| 165 | IITHGEEKD****** |
| 46 | NRDGFIDKNDLRDTF |
| 62 | ALGRVNVKNEEIDEM |
| 91 | TMFGEKLKGADPEET |
Function
Contractile protein that plays a role in heart development and function (PubMed:10409661). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity) (PubMed:10409661, PubMed:16908724, PubMed:22426213). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (PubMed:9422794)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031672 | A band |
| Cellular Component | GO:0097512 | cardiac myofibril |
| Cellular Component | GO:0043292 | contractile muscle fiber |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0030016 | myofibril |
| Cellular Component | GO:0016459 | myosin complex |
| Molecular Function | GO:0003785 | actin monomer binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0008307 | structural constituent of muscle |
| Biological Process | GO:0060048 | cardiac muscle contraction |
| Biological Process | GO:0055003 | cardiac myofibril assembly |
| Biological Process | GO:0060047 | heart contraction |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0003007 | heart morphogenesis |
| Biological Process | GO:0055001 | muscle cell development |
| Biological Process | GO:0042694 | muscle cell fate specification |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:0098735 | positive regulation of the force of heart contraction |
| Biological Process | GO:0009791 | post-embryonic development |
| Biological Process | GO:0002026 | regulation of the force of heart contraction |
| Biological Process | GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.