Search Results

Overview

Uniprot IDP51674
Protein NameNeuronal membrane glycoprotein M6-a
Gene NameGPM6A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
189 IVTIGEEKKICTVSE
190 VTIGEEKKICTVSEN
250 KDACRMQKYEDIKSK
255 MQKYEDIKSKEEQEL

Function

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor

Protein Sequence

10 MEENMEEGQT 20 QKGCFECCIK 30 CLGGIPYASL 40 IATILLYAGV 50 ALFCGCGHEA 60 LSGTVNILQT 70 YFEMARTAGD 80 TLDVFTMIDI 90 FKYVIYGIAA 100 AFFVYGILLM 110 VEGFFTTGAI 120 KDLYGDFKIT 130 TCGRCVSAWF 140 IMLTYLFMLA 150 WLGVTAFTSL 160 PVYMYFNLWT 170 ICRNTTLVEG 180 ANLCLDLRQF 190 GIVTIGEEKK 200 ICTVSENFLR 210 MCESTELNMT 220 FHLFIVALAG 230 AGAAVIAMVH 240 YLMVLSANWA 250 YVKDACRMQK 260 YEDIKSKEEQ 270 ELHDIHSTRS KERLNAYT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0044295 axonal growth cone
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0030175 filopodium
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0098688 parallel fiber to Purkinje cell synapse
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0048787 presynaptic active zone membrane
Molecular Function GO:0005262 calcium channel activity
Biological Process GO:0003407 neural retina development
Biological Process GO:0001764 neuron migration
Biological Process GO:0031175 neuron projection development
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0051491 positive regulation of filopodium assembly
Biological Process GO:0051489 regulation of filopodium assembly
Biological Process GO:0050807 regulation of synapse organization
Biological Process GO:0048863 stem cell differentiation
Biological Process GO:0007416 synapse assembly

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.