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Overview

Uniprot IDP51816
Protein NameAF4/FMR2 family member 2
Gene NameAFF2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1208 SPWVSNGKNTPSPVS
682 AHKPAPRKEPRPNIP

Function

RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure

Protein Sequence

10 MDLFDFFRDW 20 DLEQQCHYEQ 30 DRSALKKREW 40 ERRNQEVQQE 50 DDLFSSGFDL 60 FGEPYKVAEY 70 TNKGDALANR 80 VQNTLGNYDE 90 MKNLLTNHSN 100 QNHLVGIPKN 110 SVPQNPNNKN 120 EPSFFPEQKN 130 RIIPPHQDNT 140 HPSAPMPPPS 150 VVILNSTLIH 160 SNRKSKPEWS 170 RDSHNPSTVL 180 ASQASGQPNK 190 MQTLTQDQSQ 200 AKLEDFFVYP 210 AEQPQIGEVE 220 ESNPSAKEDS 230 NPNSSGEDAF 240 KEIFQSNSPE 250 ESEFAVQAPG 260 SPLVASSLLA 270 PSSGLSVQNF 280 PPGLYCKTSM 290 GQQKPTAYVR 300 PMDGQDQAPD 310 ISPTLKPSIE 320 FENSFGNLSF 330 GTLLDGKPSA 340 ASSKTKLPKF 350 TILQTSEVSL 360 PSDPSCVEEI 370 LREMTHSWPT 380 PLTSMHTAGH 390 SEQSTFSIPG 400 QESQHLTPGF 410 TLQKWNDPTT 420 RASTKSVSFK 430 SMLEDDLKLS 440 SDEDDLEPVK 450 TLTTQCTATE 460 LYQAVEKAKP 470 RNNPVNPPLA 480 TPQPPPAVQA 490 SGGSGSSSES 500 ESSSESDSDT 510 ESSTTDSESN 520 EAPRVATPEP 530 EPPSTNKWQL 540 DKWLNKVTSQ 550 NKSFICGQNE 560 TPMETISLPP 570 PIIQPMEVQM 580 KVKTNASQVP 590 AEPKERPLLS 600 LIREKARPRP 610 TQKIPETKAL 620 KHKLSTTSET 630 VSQRTIGKKQ 640 PKKVEKNTST 650 DEFTWPKPNI 660 TSSTPKEKES 670 VELHDPPRGR 680 NKATAHKPAP 690 RKEPRPNIPL 700 APEKKKYRGP 710 GKIVPKSREF 720 IETDSSTSDS 730 NTDQEETLQI 740 KVLPPCIISG 750 GNTAKSKEIC 760 GASLTLSTLM 770 SSSGSNNNLS 780 ISNEEPTFSP 790 IPVMQTEILS 800 PLRDHENLKN 810 LWVKIDLDLL 820 SRVPGHSSLH 830 AAPAKPDHKE 840 TATKPKRQTA 850 VTAVEKPAPK 860 GKRKHKPIEV 870 AEKIPEKKQR 880 LEEATTICLL 890 PPCISPAPPH 900 KPPNTRENNS 910 SRRANRRKEE 920 KLFPPPLSPL 930 PEDPPRRRNV 940 SGNNGPFGQD 950 KNIAMTGQIT 960 STKPKRTEGK 970 FCATFKGISV 980 NEGDTPKKAS 990 SATITVTNTA 1000 IATATVTATA 1010 IVTTTVTATA 1020 TATATTTTTT 1030 TTISTITSTI 1040 TTGLMDSSHL 1050 EMTSWAALPL 1060 LSSSSTNVRR 1070 PKLTFDDSVH 1080 NADYYMQEAK 1090 KLKHKADALF 1100 EKFGKAVNYA 1110 DAALSFTECG 1120 NAMERDPLEA 1130 KSPYTMYSET 1140 VELLRYAMRL 1150 KNFASPLASD 1160 GDKKLAVLCY 1170 RCLSLLYLRM 1180 FKLKKDHAMK 1190 YSRSLMEYFK 1200 QNASKVAQIP 1210 SPWVSNGKNT 1220 PSPVSLNNVS 1230 PINAMGNCNN 1240 GPVTIPQRIH 1250 HMAASHVNIT 1260 SNVLRGYEHW 1270 DMADKLTREN 1280 KEFFGDLDTL 1290 MGPLTQHSSM 1300 TNLVRYVRQG 1310 LCWLRIDAHL L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016607 nuclear speck
Molecular Function GO:0002151 G-quadruplex RNA binding
Molecular Function GO:0003712 transcription coregulator activity
Biological Process GO:0007420 brain development
Biological Process GO:0006354 DNA-templated transcription elongation
Biological Process GO:0006397 mRNA processing
Biological Process GO:0050877 nervous system process
Biological Process GO:0035063 nuclear speck organization
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0043484 regulation of RNA splicing
Biological Process GO:0008380 RNA splicing

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.