Search Results

Overview

Uniprot IDP51841
Protein NameRetinal guanylyl cyclase 2
Gene NameGUCY2F
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1107 ERQLVRNKP******

Function

Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:7777544). Plays an essential role in phototransduction, by mediating cGMP replenishment (By similarity). May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane (By similarity)

Protein Sequence

10 MFLGLGRFSR 20 LVLWFAAFRK 30 LLGHHGLASA 40 KFLWCLCLLS 50 VMSLPQQVWT 60 LPYKIGVVGP 70 WACDSLFSKA 80 LPEVAARLAI 90 ERINRDPSFD 100 LSYSFEYVIL 110 NEDCQTSRAL 120 SSFISHHQMA 130 SGFIGPTNPG 140 YCEAASLLGN 150 SWDKGIFSWA 160 CVNYELDNKI 170 SYPTFSRTLP 180 SPIRVLVTVM 190 KYFQWAHAGV 200 ISSDEDIWVH 210 TANRVASALR 220 SHGLPVGVVL 230 TTGQDSQSMR 240 KALQRIHQAD 250 RIRIIIMCMH 260 SALIGGETQM 270 HLLECAHDLK 280 MTDGTYVFVP 290 YDALLYSLPY 300 KHTPYRVLRN 310 NPKLREAYDA 320 VLTITVESQE 330 KTFYQAFTEA 340 AARGEIPEKL 350 EFDQVSPLFG 360 TIYNSIYFIA 370 QAMNNAMKEN 380 GQAGAASLVQ 390 HSRNMQFHGF 400 NQLMRTDSNG 410 NGISEYVILD 420 TNLKEWELHS 430 TYTVDMEMEL 440 LRFGGTPIHF 450 PGGRPPRADA 460 KCWFAEGKIC 470 HGGIDPAFAM 480 MVCLTLLIAL 490 LSINGFAYFI 500 RRRINKIQLI 510 KGPNRILLTL 520 EDVTFINPHF 530 GSKRGSRASV 540 SFQITSEVQS 550 GRSPRLSFSS 560 GSLTPATYEN 570 SNIAIYEGDW 580 VWLKKFSLGD 590 FGDLKSIKSR 600 ASDVFEMMKD 610 LRHENINPLL 620 GFFYDSGMFA 630 IVTEFCSRGS 640 LEDILTNQDV 650 KLDWMFKSSL 660 LLDLIKGMKY 670 LHHREFVHGR 680 LKSRNCVVDG 690 RFVLKVTDYG 700 FNDILEMLRL 710 SEEESSMEEL 720 LWTAPELLRA 730 PRGSRLGSFA 740 GDVYSFAIIM 750 QEVMVRGTPF 760 CMMDLPAQEI 770 INRLKKPPPV 780 YRPVVPPEHA 790 PPECLQLMKQ 800 CWAEAAEQRP 810 TFDEIFNQFK 820 TFNKGKKTNI 830 IDSMLRMLEQ 840 YSSNLEDLIR 850 ERTEELEIEK 860 QKTEKLLTQM 870 LPPSVAESLK 880 KGCTVEPEGF 890 DLVTLYFSDI 900 VGFTTISAMS 910 EPIEVVDLLN 920 DLYTLFDAII 930 GSHDVYKVET 940 IGDAYMVASG 950 LPKRNGSRHA 960 AEIANMSLDI 970 LSSVGTFKMR 980 HMPEVPVRIR 990 IGLHSGPVVA 1000 GVVGLTMPRY 1010 CLFGDTVNTA 1020 SRMESTGLPY 1030 RIHVSLSTVT 1040 ILQNLSEGYE 1050 VELRGRTELK 1060 GKGTEETFWL 1070 IGKKGFMKPL 1080 PVPPPVDKDG 1090 QVGHGLQPVE 1100 IAAFQRRKAE RQLVRNKP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005640 nuclear outer membrane
Cellular Component GO:0097381 photoreceptor disc membrane
Cellular Component GO:0042622 photoreceptor outer segment membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0120202 rod photoreceptor disc membrane
Cellular Component GO:0120200 rod photoreceptor outer segment
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0004383 guanylate cyclase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0001653 peptide receptor activity
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0004672 protein kinase activity
Molecular Function GO:0038023 signaling receptor activity
Biological Process GO:0006182 cGMP biosynthetic process
Biological Process GO:0050908 detection of light stimulus involved in visual perception
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0007168 receptor guanylyl cyclase signaling pathway
Biological Process GO:0022400 regulation of opsin-mediated signaling pathway
Biological Process GO:0007601 visual perception

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.