Search Results
Overview
| Uniprot ID | P51857 |
|---|---|
| Protein Name | Aldo-keto reductase family 1 member D1 |
| Gene Name | AKR1D1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 139 | YPRDENGKWLYHKSN |
| 164 | CKDAGLVKSLGVSNF |
| 188 | NKPGLKHKPVSNQVE |
| 249 | ALLNSLGKRYNKTAA |
| 253 | SLGKRYNKTAAQIVL |
Function
Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one)
Protein Sequence
10
MDLSAASHRI
20
PLSDGNSIPI
30
IGLGTYSEPK
40
STPKGACATS
50
VKVAIDTGYR
60
HIDGAYIYQN
70
EHEVGEAIRE
80
KIAEGKVRRE
90
DIFYCGKLWA
100
TNHVPEMVRP
110
TLERTLRVLQ
120
LDYVDLYIIE
130
VPMAFKPGDE
140
IYPRDENGKW
150
LYHKSNLCAT
160
WEAMEACKDA
170
GLVKSLGVSN
180
FNRRQLELIL
190
NKPGLKHKPV
200
SNQVECHPYF
210
TQPKLLKFCQ
220
QHDIVITAYS
230
PLGTSRNPIW
240
VNVSSPPLLK
250
DALLNSLGKR
260
YNKTAAQIVL
270
RFNIQRGVVV
280
IPKSFNLERI
290
KENFQIFDFS
300
LTEEEMKDIE
310
ALNKNVRFVE
320
LLMWRDHPEY
PFHDEY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0008106 | alcohol dehydrogenase (NADP+) activity |
| Molecular Function | GO:0004032 | aldose reductase (NADPH) activity |
| Molecular Function | GO:0047787 | Delta4-3-oxosteroid 5beta-reductase activity |
| Molecular Function | GO:0047086 | ketosteroid monooxygenase activity |
| Molecular Function | GO:0005496 | steroid binding |
| Molecular Function | GO:0016229 | steroid dehydrogenase activity |
| Biological Process | GO:0008209 | androgen metabolic process |
| Biological Process | GO:0006699 | bile acid biosynthetic process |
| Biological Process | GO:0030573 | bile acid catabolic process |
| Biological Process | GO:0008207 | C21-steroid hormone metabolic process |
| Biological Process | GO:0006707 | cholesterol catabolic process |
| Biological Process | GO:0007586 | digestion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.