Search Results

Overview

Uniprot IDP51858
Protein NameHepatoma-derived growth factor
Gene NameHDGF
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
105 SGYQSSQKKSCVEEP
106 GYQSSQKKSCVEEPE
11 SNRQKEYKCGDLVFA
146 LVIDEPAKEKNEKGA
151 PAKEKNEKGALKRRA
167 DLLEDSPKRPKEAEN
170 EDSPKRPKEAENPEG
197 PLPMEVEKNSTPSEP
21 DLVFAKMKGYPHWPA
39 EMPEAAVKSTANKYQ
44 AVKSTANKYQVFFFG
80 FGKPNKRKGFSEGLW

Function

Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618)

Protein Sequence

10 MSRSNRQKEY 20 KCGDLVFAKM 30 KGYPHWPARI 40 DEMPEAAVKS 50 TANKYQVFFF 60 GTHETAFLGP 70 KDLFPYEESK 80 EKFGKPNKRK 90 GFSEGLWEIE 100 NNPTVKASGY 110 QSSQKKSCVE 120 EPEPEPEAAE 130 GDGDKKGNAE 140 GSSDEEGKLV 150 IDEPAKEKNE 160 KGALKRRAGD 170 LLEDSPKRPK 180 EAENPEGEEK 190 EAATLEVERP 200 LPMEVEKNST 210 PSEPGSGRGP 220 PQEEEEEEDE 230 EEEATKEDAE 240 APGIRDHESL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0003779 actin binding
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0008083 growth factor activity
Molecular Function GO:0008201 heparin binding
Molecular Function GO:0000166 nucleotide binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0001222 transcription corepressor binding
Molecular Function GO:0015631 tubulin binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0051781 positive regulation of cell division
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0034504 protein localization to nucleus
Biological Process GO:0007165 signal transduction
Cellular Component GO:0005576 extracellular region

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[7] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[8] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[9] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[10] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[11] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.