Search Results
Overview
| Uniprot ID | P51859 |
|---|---|
| Protein Name | Hepatoma-derived growth factor |
| Gene Name | Hdgf |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | GYQSSQKKSCAAEPE |
| 39 | EMPEAAVKSTANKYQ |
Function
Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity)
Protein Sequence
10
MSRSNRQKEY
20
KCGDLVFAKM
30
KGYPHWPARI
40
DEMPEAAVKS
50
TANKYQVFFF
60
GTHETAFLGP
70
KDLFPYEESK
80
EKFGKPNKRK
90
GFSEGLWEIE
100
NNPTVKASGY
110
QSSQKKSCAA
120
EPEVEPEAHE
130
GDGDKKGSAE
140
GSSDEEGKLV
150
IDEPAKEKNE
160
KGTLKRRAGD
170
VLEDSPKRPK
180
ESGDHEEEDK
190
EIAALEGERP
200
LPVEVEKNST
210
PSEPDSGQGP
220
PAEEEEGEEE
230
AAKEEAEAQG
VRDHESL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0008083 | growth factor activity |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0001222 | transcription corepressor binding |
| Molecular Function | GO:0015631 | tubulin binding |
| Biological Process | GO:0098761 | cellular response to interleukin-7 |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051781 | positive regulation of cell division |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0034504 | protein localization to nucleus |
Reference
[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.