Search Results
Overview
| Uniprot ID | P51888 |
|---|---|
| Protein Name | Prolargin |
| Gene Name | PRELP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 148 | IDQRVLEKLPGLVFL |
| 159 | LVFLYMEKNQLEEVP |
| 213 | RLSDGVFKPDTFHGL |
| 253 | QLYLDSNKIETIPNG |
| 277 | FIRLNYNKLTDRGLP |
| 96 | CDSRNLRKVPVIPPR |
Function
May anchor basement membranes to the underlying connective tissue
Protein Sequence
10
MRSPLCWLLP
20
LLILASVAQG
30
QPTRRPRPGT
40
GPGRRPRPRP
50
RPTPSFPQPD
60
EPAEPTDLPP
70
PLPPGPPSIF
80
PDCPRECYCP
90
PDFPSALYCD
100
SRNLRKVPVI
110
PPRIHYLYLQ
120
NNFITELPVE
130
SFQNATGLRW
140
INLDNNRIRK
150
IDQRVLEKLP
160
GLVFLYMEKN
170
QLEEVPSALP
180
RNLEQLRLSQ
190
NHISRIPPGV
200
FSKLENLLLL
210
DLQHNRLSDG
220
VFKPDTFHGL
230
KNLMQLNLAH
240
NILRKMPPRV
250
PTAIHQLYLD
260
SNKIETIPNG
270
YFKSFPNLAF
280
IRLNYNKLTD
290
RGLPKNSFNI
300
SNLLVLHLSH
310
NRISSVPAIN
320
NRLEHLYLNN
330
NSIEKINGTQ
340
ICPNDLVAFH
350
DFSSDLENVP
360
HLRYLRLDGN
370
YLKPPIPLDL
380
MMCFRLLQSV
VI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1903561 | extracellular vesicle |
| Cellular Component | GO:0140150 | gel phase of interstitial matrix |
| Cellular Component | GO:0005796 | Golgi lumen |
| Cellular Component | GO:0043202 | lysosomal lumen |
| Molecular Function | GO:0005201 | extracellular matrix structural constituent |
| Molecular Function | GO:0030021 | extracellular matrix structural constituent conferring compression resistance |
| Molecular Function | GO:0008201 | heparin binding |
| Biological Process | GO:0001501 | skeletal system development |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.