Search Results
Overview
| Uniprot ID | P51911 |
|---|---|
| Protein Name | Calponin-1 |
| Gene Name | CNN1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 19 | YGLSAEVKNKLAQKY |
| 225 | GMTAPGTKRQIFEPG |
| 55 | NNFMDGLKDGIILCE |
| 66 | ILCEFINKLQPGSVK |
Function
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)
Protein Sequence
10
MSSAHFNRGP
20
AYGLSAEVKN
30
KLAQKYDHQR
40
EQELREWIEG
50
VTGRRIGNNF
60
MDGLKDGIIL
70
CEFINKLQPG
80
SVKKINESTQ
90
NWHQLENIGN
100
FIKAITKYGV
110
KPHDIFEAND
120
LFENTNHTQV
130
QSTLLALASM
140
AKTKGNKVNV
150
GVKYAEKQER
160
KFEPGKLREG
170
RNIIGLQMGT
180
NKFASQQGMT
190
AYGTRRHLYD
200
PKLGTDQPLD
210
QATISLQMGT
220
NKGASQAGMT
230
APGTKRQIFE
240
PGLGMEHCDT
250
LNVSLQMGSN
260
KGASQRGMTV
270
YGLPRQVYDP
280
KYCLTPEYPE
290
LGEPAHNHHA
HNYYNSA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005925 | focal adhesion |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0031032 | actomyosin structure organization |
| Biological Process | GO:1904706 | negative regulation of vascular associated smooth muscle cell proliferation |
| Biological Process | GO:0006940 | regulation of smooth muscle contraction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.