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Overview

Uniprot IDP51946
Protein NameCyclin-H
Gene NameCCNH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
295 NVITKKRKGYEDDDY
305 EDDDYVSKKSKHEEE
306 DDDYVSKKSKHEEEE

Function

Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs (PubMed:41100585). Binds and activates cyclin-dependent protein kinase CDK7, the catalytic subunit of CAK (PubMed:41100585). CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts (PubMed:7533895, PubMed:10024882). Involved in cell cycle control and in RNA transcription by RNA polymerase II (PubMed:7533895, PubMed:10024882). Its expression and activity are constant throughout the cell cycle

Protein Sequence

10 MYHNSSQKRH 20 WTFSSEEQLA 30 RLRADANRKF 40 RCKAVANGKV 50 LPNDPVFLEP 60 HEEMTLCKYY 70 EKRLLEFCSV 80 FKPAMPRSVV 90 GTACMYFKRF 100 YLNNSVMEYH 110 PRIIMLTCAF 120 LACKVDEFNV 130 SSPQFVGNLR 140 ESPLGQEKAL 150 EQILEYELLL 160 IQQLNFHLIV 170 HNPYRPFEGF 180 LIDLKTRYPI 190 LENPEILRKT 200 ADDFLNRIAL 210 TDAYLLYTPS 220 QIALTAILSS 230 ASRAGITMES 240 YLSESLMLKE 250 NRTCLSQLLD 260 IMKSMRNLVK 270 KYEPPRSEEV 280 AVLKQKLERC 290 HSAELALNVI 300 TKKRKGYEDD 310 DYVSKKSKHE 320 EEEWTDDDLV ESL

Gene Ontology

Classification GO ID Description
Biological Process GO:0006289 nucleotide-excision repair
Cellular Component GO:0070516 CAK-ERCC2 complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000439 transcription factor TFIIH core complex
Cellular Component GO:0005675 transcription factor TFIIH holo complex
Cellular Component GO:0070985 transcription factor TFIIK complex
Molecular Function GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Molecular Function GO:0016301 kinase activity
Biological Process GO:0050821 protein stabilization
Biological Process GO:2000045 regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0006367 transcription initiation at RNA polymerase II promoter

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.