Search Results
Overview
| Uniprot ID | P51957 |
|---|---|
| Protein Name | Serine/threonine-protein kinase Nek4 |
| Gene Name | NEK4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 690 | SSTSSTDKSDGDYGE |
Function
Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage
Protein Sequence
10
MPLAAYCYLR
20
VVGKGSYGEV
30
TLVKHRRDGK
40
QYVIKKLNLR
50
NASSRERRAA
60
EQEAQLLSQL
70
KHPNIVTYKE
80
SWEGGDGLLY
90
IVMGFCEGGD
100
LYRKLKEQKG
110
QLLPENQVVE
120
WFVQIAMALQ
130
YLHEKHILHR
140
DLKTQNVFLT
150
RTNIIKVGDL
160
GIARVLENHC
170
DMASTLIGTP
180
YYMSPELFSN
190
KPYNYKSDVW
200
ALGCCVYEMA
210
TLKHAFNAKD
220
MNSLVYRIIE
230
GKLPPMPRDY
240
SPELAELIRT
250
MLSKRPEERP
260
SVRSILRQPY
270
IKRQISFFLE
280
ATKIKTSKNN
290
IKNGDSQSKP
300
FATVVSGEAE
310
SNHEVIHPQP
320
LSSEGSQTYI
330
MGEGKCLSQE
340
KPRASGLLKS
350
PASLKAHTCK
360
QDLSNTTELA
370
TISSVNIDIL
380
PAKGRDSVSD
390
GFVQENQPRY
400
LDASNELGGI
410
CSISQVEEEM
420
LQDNTKSSAQ
430
PENLIPMWSS
440
DIVTGEKNEP
450
VKPLQPLIKE
460
QKPKDQSLAL
470
SPKLECSGTI
480
LAHSNLRLLG
490
SSDSPASASR
500
VAGITGVCHH
510
AQDQVAGECI
520
IEKQGRIHPD
530
LQPHNSGSEP
540
SLSRQRRQKR
550
REQTEHRGEK
560
RQVRRDLFAF
570
QESPPRFLPS
580
HPIVGKVDVT
590
STQKEAENQR
600
RVVTGSVSSS
610
RSSEMSSSKD
620
RPLSARERRR
630
LKQSQEEMSS
640
SGPSVRKASL
650
SVAGPGKPQE
660
EDQPLPARRL
670
SSDCSVTQER
680
KQIHCLSEDE
690
LSSSTSSTDK
700
SDGDYGEGKG
710
QTNEINALVQ
720
LMTQTLKLDS
730
KESCEDVPVA
740
NPVSEFKLHR
750
KYRDTLILHG
760
KVAEEAEEIH
770
FKELPSAIMP
780
GSEKIRRLVE
790
VLRTDVIRGL
800
GVQLLEQVYD
810
LLEEEDEFDR
820
EVRLREHMGE
830
KYTTYSVKAR
840
QLKFFEENMN
F
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:2000772 | regulation of cellular senescence |
| Biological Process | GO:1904062 | regulation of monoatomic cation transmembrane transport |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.