Search Results

Overview

Uniprot ID	P51991
Protein Name	Heterogeneous nuclear ribonucleoprotein A3
Gene Name	HNRNPA3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
118	VSREDSVKPGAHLTV
126	PGAHLTVKKIFVGGI
127	GAHLTVKKIFVGGIK
134	KIFVGGIKEDTEEYN
187	VDKIVVQKYHTINGH
57	SLREHFEKWGTLTDC

Function

Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing

Protein Sequence

10 MEVKPPPGRP 20 QPDSGRRRRR 30 RGEEGHDPKE 40 PEQLRKLFIG 50 GLSFETTDDS 60 LREHFEKWGT 70 LTDCVVMRDP 80 QTKRSRGFGF 90 VTYSCVEEVD 100 AAMCARPHKV 110 DGRVVEPKRA 120 VSREDSVKPG 130 AHLTVKKIFV 140 GGIKEDTEEY 150 NLRDYFEKYG 160 KIETIEVMED 170 RQSGKKRGFA 180 FVTFDDHDTV 190 DKIVVQKYHT 200 INGHNCEVKK 210 ALSKQEMQSA 220 GSQRGRGGGS 230 GNFMGRGGNF 240 GGGGGNFGRG 250 GNFGGRGGYG 260 GGGGGSRGSY 270 GGGDGGYNGF 280 GGDGGNYGGG 290 PGYSSRGGYG 300 GGGPGYGNQG 310 GGYGGGGGYD 320 GYNEGGNFGG 330 GNYGGGGNYN 340 DFGNYSGQQQ 350 SNYGPMKGGS 360 FGGRSSGSPY 370 GGGYGSGGGS GGYGSRRF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0071013	catalytic step 2 spliceosome
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:1990904	ribonucleoprotein complex
Molecular Function	GO:0003730	mRNA 3'-UTR binding
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0000398	mRNA splicing, via spliceosome

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.