Search Results

Overview

Uniprot ID	P52179
Protein Name	Myomesin-1
Gene Name	MYOM1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1083	DLKEAKAKEDQWRGL
312	EPRVTWYKNQVPINV
548	ILGYFIDKCEVGTDS

Function

Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent

Protein Sequence

10 MSLPFYQRCH 20 QHYDLSYRNK 30 DVRSTVSHYQ 40 REKKRSAVYT 50 QGSTAYSSRS 60 SAAHRRESEA 70 FRRASASSSQ 80 QQASQHALSS 90 EVSRKAASAY 100 DYGSSHGLTD 110 SSLLLDDYSS 120 KLSPKPKRAK 130 HSLLSGEEKE 140 NLPSDYMVPI 150 FSGRQKHVSG 160 ITDTEEERIK 170 EAAAYIAQRN 180 LLASEEGITT 190 SKQSTASKQT 200 TASKQSTASK 210 QSTASKQSTA 220 SRQSTASRQS 230 VVSKQATSAL 240 QQEETSEKKS 250 RKVVIREKAE 260 RLSLRKTLEE 270 TETYHAKLNE 280 DHLLHAPEFI 290 IKPRSHTVWE 300 KENVKLHCSI 310 AGWPEPRVTW 320 YKNQVPINVH 330 ANPGKYIIES 340 RYGMHTLEIN 350 GCDFEDTAQY 360 RASAMNVKGE 370 LSAYASVVVK 380 RYKGEFDETR 390 FHAGASTMPL 400 SFGVTPYGYA 410 SRFEIHFDDK 420 FDVSFGREGE 430 TMSLGCRVVI 440 TPEIKHFQPE 450 IQWYRNGVPL 460 SPSKWVQTLW 470 SGERATLTFS 480 HLNKEDEGLY 490 TIRVRMGEYY 500 EQYSAYVFVR 510 DADAEIEGAP 520 AAPLDVKCLE 530 ANKDYIIISW 540 KQPAVDGGSP 550 ILGYFIDKCE 560 VGTDSWSQCN 570 DTPVKFARFP 580 VTGLIEGRSY 590 IFRVRAVNKM 600 GIGFPSRVSE 610 PVAALDPAEK 620 ARLKSRPSAP 630 WTGQIIVTEE 640 EPSEGIVPGP 650 PTDLSVTEAT 660 RSYVVLSWKP 670 PGQRGHEGIM 680 YFVEKCEAGT 690 ENWQRVNTEL 700 PVKSPRFALF 710 DLAEGKSYCF 720 RVRCSNSAGV 730 GEPSEATEVT 740 VVGDKLDIPK 750 APGKIIPSRN 760 TDTSVVVSWE 770 ESKDAKELVG 780 YYIEASVAGS 790 GKWEPCNNNP 800 VKGSRFTCHG 810 LVTGQSYIFR 820 VRAVNAAGLS 830 EYSQDSEAIE 840 VKAAIGGGVS 850 PDVCPALSDE 860 PGGLTASRGR 870 VHEASPPTFQ 880 KDALLGSKPN 890 KPSLPSSSQN 900 LGQTEVSKVS 910 ETVQEELTPP 920 PQKAAPQGKS 930 KSDPLKKKTD 940 RAPPSPPCDI 950 TCLESFRDSM 960 VLGWKQPDKI 970 GGAEITGYYV 980 NYREVIDGVP 990 GKWREANVKA 1000 VSEEAYKISN 1010 LKENMVYQFQ 1020 VAAMNMAGLG 1030 APSAVSECFK 1040 CEEWTIAVPG 1050 PPHSLKCSEV 1060 RKDSLVLQWK 1070 PPVHSGRTPV 1080 TGYFVDLKEA 1090 KAKEDQWRGL 1100 NEAAIKNVYL 1110 KVRGLKEGVS 1120 YVFRVRAINQ 1130 AGVGKPSDLA 1140 GPVVAETRPG 1150 TKEVVVNVDD 1160 DGVISLNFEC 1170 DKMTPKSEFS 1180 WSKDYVSTED 1190 SPRLEVESKG 1200 NKTKMTFKDL 1210 GMDDLGIYSC 1220 DVTDTDGIAS 1230 SYLIDEEELK 1240 RLLALSHEHK 1250 FPTVPVKSEL 1260 AVEILEKGQV 1270 RFWMQAEKLS 1280 GNAKVNYIFN 1290 EKEIFEGPKY 1300 KMHIDRNTGI 1310 IEMFMEKLQD 1320 EDEGTYTFQL 1330 QDGKATNHST 1340 VVLVGDVFKK 1350 LQKEAEFQRQ 1360 EWIRKQGPHF 1370 VEYLSWEVTG 1380 ECNVLLKCKV 1390 ANIKKETHIV 1400 WYKDEREISV 1410 DEKHDFKDGI 1420 CTLLITEFSK 1430 KDAGIYEVIL 1440 KDDRGKDKSR 1450 LKLVDEAFKE 1460 LMMEVCKKIA 1470 LSATDLKIQS 1480 TAEGIQLYSF 1490 VTYYVEDLKV 1500 NWSHNGSAIR 1510 YSDRVKTGVT 1520 GEQIWLQINE 1530 PTPNDKGKYV 1540 MELFDGKTGH 1550 QKTVDLSGQA 1560 YDEAYAEFQR 1570 LKQAAIAEKN 1580 RARVLGGLPD 1590 VVTIQEGKAL 1600 NLTCNVWGDP 1610 PPEVSWLKNE 1620 KALASDDHCN 1630 LKFEAGRTAY 1640 FTINGVSTAD 1650 SGKYGLVVKN 1660 KYGSETSDFT 1670 VSVFIPEEEA 1680 RMAALESLKG GKKAK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031430	M band
Cellular Component	GO:0005863	striated muscle myosin thick filament
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0019900	kinase binding
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0008307	structural constituent of muscle
Biological Process	GO:0002074	extraocular skeletal muscle development
Biological Process	GO:0141163	positive regulation of cAMP/PKA signal transduction
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0045214	sarcomere organization

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.