Search Results

Overview

Uniprot IDP52209
Protein Name6-phosphogluconate dehydrogenase, decarboxylating
Gene NamePGD
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
119 RCRDLKAKGILFVGS
248 KFQDTDGKHLLPKIR
253 DGKHLLPKIRDSAGQ
261 IRDSAGQKGTGKWTA
309 KKLKGPQKFQFDGDK
316 KFQFDGDKKSFLEDI
317 FQFDGDKKSFLEDIR
38 AFNRTVSKVDDFLAN
48 DFLANEAKGTKVVGA
51 ANEAKGTKVVGAQSL
59 VVGAQSLKEMVSKLK

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH

Protein Sequence

10 MAQADIALIG 20 LAVMGQNLIL 30 NMNDHGFVVC 40 AFNRTVSKVD 50 DFLANEAKGT 60 KVVGAQSLKE 70 MVSKLKKPRR 80 IILLVKAGQA 90 VDDFIEKLVP 100 LLDTGDIIID 110 GGNSEYRDTT 120 RRCRDLKAKG 130 ILFVGSGVSG 140 GEEGARYGPS 150 LMPGGNKEAW 160 PHIKTIFQGI 170 AAKVGTGEPC 180 CDWVGDEGAG 190 HFVKMVHNGI 200 EYGDMQLICE 210 AYHLMKDVLG 220 MAQDEMAQAF 230 EDWNKTELDS 240 FLIEITANIL 250 KFQDTDGKHL 260 LPKIRDSAGQ 270 KGTGKWTAIS 280 ALEYGVPVTL 290 IGEAVFARCL 300 SSLKDERIQA 310 SKKLKGPQKF 320 QFDGDKKSFL 330 EDIRKALYAS 340 KIISYAQGFM 350 LLRQAATEFG 360 WTLNYGGIAL 370 MWRGGCIIRS 380 VFLGKIKDAF 390 DRNPELQNLL 400 LDDFFKSAVE 410 NCQDSWRRAV 420 STGVQAGIPM 430 PCFTTALSFY 440 DGYRHEMLPA 450 SLIQAQRDYF 460 GAHTYELLAK 470 PGQFIHTNWT 480 GHGGTVSSSS YNA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005634 nucleus
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0031406 carboxylic acid binding
Molecular Function GO:0050661 NADP binding
Molecular Function GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
Biological Process GO:0019521 D-gluconate metabolic process
Biological Process GO:0006098 pentose-phosphate shunt
Biological Process GO:0009051 pentose-phosphate shunt, oxidative branch

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.