Search Results

Overview

Uniprot IDP52272
Protein NameHeterogeneous nuclear ribonucleoprotein M
Gene NameHNRNPM
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
127 KMEESMKKAAEVLNK
134 KAAEVLNKHSLSGRP
145 SGRPLKVKEDPDGEH
239 RADILEDKDGKSRGI
381 EILSNALKRGEIIAK
388 KRGEIIAKQGGGGGG
48 ERPAQNEKRKEKNIK
651 HAPGVARKACQIFVR
69 EPYANPTKRYRAFIT
698 SKGCGVVKFESPEVA

Function

Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines

Protein Sequence

10 MAAGVEAAAE 20 VAATEIKMEE 30 ESGAPGVPSG 40 NGAPGPKGEG 50 ERPAQNEKRK 60 EKNIKRGGNR 70 FEPYANPTKR 80 YRAFITNIPF 90 DVKWQSLKDL 100 VKEKVGEVTY 110 VELLMDAEGK 120 SRGCAVVEFK 130 MEESMKKAAE 140 VLNKHSLSGR 150 PLKVKEDPDG 160 EHARRAMQKV 170 MATTGGMGMG 180 PGGPGMITIP 190 PSILNNPNIP 200 NEIIHALQAG 210 RLGSTVFVAN 220 LDYKVGWKKL 230 KEVFSMAGVV 240 VRADILEDKD 250 GKSRGIGTVT 260 FEQSIEAVQA 270 ISMFNGQLLF 280 DRPMHVKMDE 290 RALPKGDFFP 300 PERPQQLPHG 310 LGGIGMGLGP 320 GGQPIDANHL 330 NKGIGMGNIG 340 PAGMGMEGIG 350 FGINKMGGME 360 GPFGGGMENM 370 GRFGSGMNMG 380 RINEILSNAL 390 KRGEIIAKQG 400 GGGGGGSVPG 410 IERMGPGIDR 420 LGGAGMERMG 430 AGLGHGMDRV 440 GSEIERMGLV 450 MDRMGSVERM 460 GSGIERMGPL 470 GLDHMASSIE 480 RMGQTMERIG 490 SGVERMGAGM 500 GFGLERMAAP 510 IDRVGQTIER 520 MGSGVERMGP 530 AIERMGLSME 540 RMVPAGMGAG 550 LERMGPVMDR 560 MATGLERMGA 570 NNLERMGLER 580 MGANSLERMG 590 LERMGANSLE 600 RMGPAMGPAL 610 GAGIERMGLA 620 MGGGGGASFD 630 RAIEMERGNF 640 GGSFAGSFGG 650 AGGHAPGVAR 660 KACQIFVRNL 670 PFDFTWKMLK 680 DKFNECGHVL 690 YADIKMENGK 700 SKGCGVVKFE 710 SPEVAERACR 720 MMNGMKLSGR 730 EIDVRIDRNA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0042382 paraspeckles
Cellular Component GO:0005681 spliceosomal complex
Cellular Component GO:0045202 synapse
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000380 alternative mRNA splicing, via spliceosome
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[7] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.