Search Results
Overview
| Uniprot ID | P52434 |
|---|---|
| Protein Name | DNA-directed RNA polymerases I, II, and III subunit RPABC3 |
| Gene Name | POLR2H |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 20 | KDIDPEGKKFDRVSR |
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively
Protein Sequence
10
MAGILFEDIF
20
DVKDIDPEGK
30
KFDRVSRLHC
40
ESESFKMDLI
50
LDVNIQIYPV
60
DLGDKFRLVI
70
ASTLYEDGTL
80
DDGEYNPTDD
90
RPSRADQFEY
100
VMYGKVYRIE
110
GDETSTEAAT
120
RLSAYVSYGG
130
LLMRLQGDAN
140
NLHGFEVDSR
150
VYLLMKKLAF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032993 | protein-DNA complex |
| Cellular Component | GO:0005736 | RNA polymerase I complex |
| Cellular Component | GO:0005665 | RNA polymerase II, core complex |
| Cellular Component | GO:0005666 | RNA polymerase III complex |
| Molecular Function | GO:0003899 | DNA-directed RNA polymerase activity |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Biological Process | GO:0042790 | nucleolar large rRNA transcription by RNA polymerase I |
| Biological Process | GO:0006363 | termination of RNA polymerase I transcription |
| Biological Process | GO:0006386 | termination of RNA polymerase III transcription |
| Biological Process | GO:0006366 | transcription by RNA polymerase II |
| Biological Process | GO:0006383 | transcription by RNA polymerase III |
| Biological Process | GO:0006362 | transcription elongation by RNA polymerase I |
| Biological Process | GO:0006368 | transcription elongation by RNA polymerase II |
| Biological Process | GO:0006361 | transcription initiation at RNA polymerase I promoter |
| Biological Process | GO:0006367 | transcription initiation at RNA polymerase II promoter |
| Biological Process | GO:0006384 | transcription initiation at RNA polymerase III promoter |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.