Search Results
Overview
| Uniprot ID | P52503 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial |
| Gene Name | Ndufs6 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | INLDKETKTGTCGYC |
| 41 | TGQVYDEKDYRRVRF |
| 97 | KVYINLDKETKTGTC |
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Biological Process | GO:0009060 | aerobic respiration |
| Biological Process | GO:0090398 | cellular senescence |
| Biological Process | GO:0072359 | circulatory system development |
| Biological Process | GO:0030330 | DNA damage response, signal transduction by p53 class mediator |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0001822 | kidney development |
| Biological Process | GO:0072497 | mesenchymal stem cell differentiation |
| Biological Process | GO:0097168 | mesenchymal stem cell proliferation |
| Biological Process | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| Biological Process | GO:0032981 | mitochondrial respiratory chain complex I assembly |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:0035264 | multicellular organism growth |
| Biological Process | GO:0006936 | muscle contraction |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
| Biological Process | GO:0072593 | reactive oxygen species metabolic process |
| Biological Process | GO:0051881 | regulation of mitochondrial membrane potential |
| Biological Process | GO:0061458 | reproductive system development |
| Biological Process | GO:0022904 | respiratory electron transport chain |
| Biological Process | GO:0017145 | stem cell division |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.