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Overview

Uniprot IDP52566
Protein NameRho GDP-dissociation inhibitor 2
Gene NameARHGDIB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
102 KKETIVLKEGSEYRV
124 RDIVSGLKYVQHTYR
135 HTYRTGVKVDKATFM
21 DDDELDSKLNYKPPP
30 NYKPPPQKSLKELQE
33 PPPQKSLKELQEMDK
4 ****MTEKAPEPHVE
50 ESLIKYKKTLLGDGP
63 GPVVTDPKAPNVVVT
96 GDLEALKKETIVLKE

Function

Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:7512369, PubMed:8356058). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133)

Protein Sequence

10 MTEKAPEPHV 20 EEDDDDELDS 30 KLNYKPPPQK 40 SLKELQEMDK 50 DDESLIKYKK 60 TLLGDGPVVT 70 DPKAPNVVVT 80 RLTLVCESAP 90 GPITMDLTGD 100 LEALKKETIV 110 LKEGSEYRVK 120 IHFKVNRDIV 130 SGLKYVQHTY 140 RTGVKVDKAT 150 FMVGSYGPRP 160 EEYEFLTPVE 170 EAPKGMLARG 180 TYHNKSFFTD 190 DDKQDHLSWE 200 WNLSIKKEWT E

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0005094 Rho GDP-dissociation inhibitor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0071461 cellular response to redox state
Biological Process GO:1901164 negative regulation of trophoblast cell migration
Biological Process GO:0035023 regulation of Rho protein signal transduction
Biological Process GO:0007266 Rho protein signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.