Search Results

Overview

Uniprot ID	P52594
Protein Name	Arf-GAP domain and FG repeat-containing protein 1
Gene Name	AGFG1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
175	APTLHLNKGTPSQSP
313	QTASAVSKVSTNKAG
318	VSKVSTNKAGLQTAD

Function

Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication

Protein Sequence

10 MAASAKRKQE 20 EKHLKMLRDM 30 TGLPHNRKCF 40 DCDQRGPTYV 50 NMTVGSFVCT 60 SCSGSLRGLN 70 PPHRVKSISM 80 TTFTQQEIEF 90 LQKHGNEVCK 100 QIWLGLFDDR 110 SSAIPDFRDP 120 QKVKEFLQEK 130 YEKKRWYVPP 140 EQAKVVASVH 150 ASISGSSASS 160 TSSTPEVKPL 170 KSLLGDSAPT 180 LHLNKGTPSQ 190 SPVVGRSQGQ 200 QQEKKQFDLL 210 SDLGSDIFAA 220 PAPQSTATAN 230 FANFAHFNSH 240 AAQNSANADF 250 ANFDAFGQSS 260 GSSNFGGFPT 270 ASHSPFQPQT 280 TGGSAASVNA 290 NFAHFDNFPK 300 SSSADFGTFN 310 TSQSHQTASA 320 VSKVSTNKAG 330 LQTADKYAAL 340 ANLDNIFSAG 350 QGGDQGSGFG 360 TTGKAPVGSV 370 VSVPSQSSAS 380 SDKYAALAEL 390 DSVFSSAATS 400 SNAYTSTSNA 410 SSNVFGTVPV 420 VASAQTQPAS 430 SSVPAPFGAT 440 PSTNPFVAAA 450 GPSVASSTNP 460 FQTNARGATA 470 ATFGTASMSM 480 PTGFGTPAPY 490 SLPTSFSGSF 500 QQPAFPAQAA 510 FPQQTAFSQQ 520 PNGAGFAAFG 530 QTKPVVTPFG 540 QVAAAGVSSN 550 PFMTGAPTGQ 560 FPTGSSSTNP FL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0042995	cell projection
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0031410	cytoplasmic vesicle
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005643	nuclear pore
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0001675	acrosome assembly
Biological Process	GO:0045109	intermediate filament organization
Biological Process	GO:0006406	mRNA export from nucleus
Biological Process	GO:0007289	spermatid nucleus differentiation
Cellular Component	GO:0005829	cytosol

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[7] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.