Search Results

Overview

Uniprot IDP52630
Protein NameSignal transducer and activator of transcription 2
Gene NameSTAT2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
184 YKIQAKGKTPSLDPH

Function

Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188)

Protein Sequence

10 MAQWEMLQNL 20 DSPFQDQLHQ 30 LYSHSLLPVD 40 IRQYLAVWIE 50 DQNWQEAALG 60 SDDSKATMLF 70 FHFLDQLNYE 80 CGRCSQDPES 90 LLLQHNLRKF 100 CRDIQPFSQD 110 PTQLAEMIFN 120 LLLEEKRILI 130 QAQRAQLEQG 140 EPVLETPVES 150 QQHEIESRIL 160 DLRAMMEKLV 170 KSISQLKDQQ 180 DVFCFRYKIQ 190 AKGKTPSLDP 200 HQTKEQKILQ 210 ETLNELDKRR 220 KEVLDASKAL 230 LGRLTTLIEL 240 LLPKLEEWKA 250 QQQKACIRAP 260 IDHGLEQLET 270 WFTAGAKLLF 280 HLRQLLKELK 290 GLSCLVSYQD 300 DPLTKGVDLR 310 NAQVTELLQR 320 LLHRAFVVET 330 QPCMPQTPHR 340 PLILKTGSKF 350 TVRTRLLVRL 360 QEGNESLTVE 370 VSIDRNPPQL 380 QGFRKFNILT 390 SNQKTLTPEK 400 GQSQGLIWDF 410 GYLTLVEQRS 420 GGSGKGSNKG 430 PLGVTEELHI 440 ISFTVKYTYQ 450 GLKQELKTDT 460 LPVVIISNMN 470 QLSIAWASVL 480 WFNLLSPNLQ 490 NQQFFSNPPK 500 APWSLLGPAL 510 SWQFSSYVGR 520 GLNSDQLSML 530 RNKLFGQNCR 540 TEDPLLSWAD 550 FTKRESPPGK 560 LPFWTWLDKI 570 LELVHDHLKD 580 LWNDGRIMGF 590 VSRSQERRLL 600 KKTMSGTFLL 610 RFSESSEGGI 620 TCSWVEHQDD 630 DKVLIYSVQP 640 YTKEVLQSLP 650 LTEIIRHYQL 660 LTEENIPENP 670 LRFLYPRIPR 680 DEAFGCYYQE 690 KVNLQERRKY 700 LKHRLIVVSN 710 RQVDELQQPL 720 ELKPEPELES 730 LELELGLVPE 740 PELSLDLEPL 750 LKAGLDLGPE 760 LESVLESTLE 770 PVIEPTLCMV 780 SQTVPEPDQG 790 PVSQPVPEPD 800 LPCDLRHLNT 810 EPMEIFRNCV 820 KIEEIMPNGD 830 PLLAGQNTVD 840 EVYVSRPSHF 850 YTDGPLMPSD F

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0044389 ubiquitin-like protein ligase binding
Biological Process GO:0007259 cell surface receptor signaling pathway via JAK-STAT
Biological Process GO:0006952 defense response
Biological Process GO:0051607 defense response to virus
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0060339 negative regulation of type I interferon-mediated signaling pathway
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0090140 regulation of mitochondrial fission
Biological Process GO:0001932 regulation of protein phosphorylation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0043434 response to peptide hormone
Biological Process GO:0060337 type I interferon-mediated signaling pathway
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070721 ISGF3 complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.