Search Results
Overview
| Uniprot ID | P52732 |
|---|---|
| Protein Name | Kinesin-like protein KIF11 |
| Gene Name | KIF11 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1045 | TTEHLVTKSRLPLRA |
| 146 | TLHQIFEKLTDNGTE |
| 930 | TGTTPQRKSYLYPST |
Function
Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769)
Protein Sequence
10
MASQPNSSAK
20
KKEEKGKNIQ
30
VVVRCRPFNL
40
AERKASAHSI
50
VECDPVRKEV
60
SVRTGGLADK
70
SSRKTYTFDM
80
VFGASTKQID
90
VYRSVVCPIL
100
DEVIMGYNCT
110
IFAYGQTGTG
120
KTFTMEGERS
130
PNEEYTWEED
140
PLAGIIPRTL
150
HQIFEKLTDN
160
GTEFSVKVSL
170
LEIYNEELFD
180
LLNPSSDVSE
190
RLQMFDDPRN
200
KRGVIIKGLE
210
EITVHNKDEV
220
YQILEKGAAK
230
RTTAATLMNA
240
YSSRSHSVFS
250
VTIHMKETTI
260
DGEELVKIGK
270
LNLVDLAGSE
280
NIGRSGAVDK
290
RAREAGNINQ
300
SLLTLGRVIT
310
ALVERTPHVP
320
YRESKLTRIL
330
QDSLGGRTRT
340
SIIATISPAS
350
LNLEETLSTL
360
EYAHRAKNIL
370
NKPEVNQKLT
380
KKALIKEYTE
390
EIERLKRDLA
400
AAREKNGVYI
410
SEENFRVMSG
420
KLTVQEEQIV
430
ELIEKIGAVE
440
EELNRVTELF
450
MDNKNELDQC
460
KSDLQNKTQE
470
LETTQKHLQE
480
TKLQLVKEEY
490
ITSALESTEE
500
KLHDAASKLL
510
NTVEETTKDV
520
SGLHSKLDRK
530
KAVDQHNAEA
540
QDIFGKNLNS
550
LFNNMEELIK
560
DGSSKQKAML
570
EVHKTLFGNL
580
LSSSVSALDT
590
ITTVALGSLT
600
SIPENVSTHV
610
SQIFNMILKE
620
QSLAAESKTV
630
LQELINVLKT
640
DLLSSLEMIL
650
SPTVVSILKI
660
NSQLKHIFKT
670
SLTVADKIED
680
QKKELDGFLS
690
ILCNNLHELQ
700
ENTICSLVES
710
QKQCGNLTED
720
LKTIKQTHSQ
730
ELCKLMNLWT
740
ERFCALEEKC
750
ENIQKPLSSV
760
QENIQQKSKD
770
IVNKMTFHSQ
780
KFCADSDGFS
790
QELRNFNQEG
800
TKLVEESVKH
810
SDKLNGNLEK
820
ISQETEQRCE
830
SLNTRTVYFS
840
EQWVSSLNER
850
EQELHNLLEV
860
VSQCCEASSS
870
DITEKSDGRK
880
AAHEKQHNIF
890
LDQMTIDEDK
900
LIAQNLELNE
910
TIKIGLTKLN
920
CFLEQDLKLD
930
IPTGTTPQRK
940
SYLYPSTLVR
950
TEPREHLLDQ
960
LKRKQPELLM
970
MLNCSENNKE
980
ETIPDVDVEE
990
AVLGQYTEEP
1000
LSQEPSVDAG
1010
VDCSSIGGVP
1020
FFQHKKSHGK
1030
DKENRGINTL
1040
ERSKVEETTE
1050
HLVTKSRLPL
RAQINL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005819 | spindle |
| Cellular Component | GO:0000922 | spindle pole |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0003777 | microtubule motor activity |
| Molecular Function | GO:0008574 | plus-end-directed microtubule motor activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0007018 | microtubule-based movement |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0090307 | mitotic spindle assembly |
| Biological Process | GO:0007052 | mitotic spindle organization |
| Biological Process | GO:0046602 | regulation of mitotic centrosome separation |
| Biological Process | GO:0051231 | spindle elongation |
| Biological Process | GO:0007051 | spindle organization |
| Cellular Component | GO:0005871 | kinesin complex |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.