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Overview

Uniprot IDP52756
Protein NameRNA-binding protein 5
Gene NameRBM5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
181 HYSNPRPKFEDWLCN
268 NIRLIKDKQTQQNRG
318 DFAKSARKDLVLSDG
535 KKEKPKSKTAQQIAK
542 KTAQQIAKDMERWAK
553 RWAKSLNKQKENFKN
613 GDEENPLKRGLVAAY
711 RAAERREKYGIPEPP
721 IPEPPEPKRKKQFDA
724 PPEPKRKKQFDAGTV
780 IEAQVRLKGAGLGAK

Function

Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis

Protein Sequence

10 MGSDKRVSRT 20 ERSGRYGSII 30 DRDDRDERES 40 RSRRRDSDYK 50 RSSDDRRGDR 60 YDDYRDYDSP 70 ERERERRNSD 80 RSEDGYHSDG 90 DYGEHDYRHD 100 ISDERESKTI 110 MLRGLPITIT 120 ESDIREMMES 130 FEGPQPADVR 140 LMKRKTGVSR 150 GFAFVEFYHL 160 QDATSWMEAN 170 QKKLVIQGKH 180 IAMHYSNPRP 190 KFEDWLCNKC 200 CLNNFRKRLK 210 CFRCGADKFD 220 SEQEVPPGTT 230 ESVQSVDYYC 240 DTIILRNIAP 250 HTVVDSIMTA 260 LSPYASLAVN 270 NIRLIKDKQT 280 QQNRGFAFVQ 290 LSSAMDASQL 300 LQILQSLHPP 310 LKIDGKTIGV 320 DFAKSARKDL 330 VLSDGNRVSA 340 FSVASTAIAA 350 AQWSSTQSQS 360 GEGGSVDYSY 370 LQPGQDGYAQ 380 YAQYSQDYQQ 390 FYQQQAGGLE 400 SDASSASGTA 410 VTTTSAAVVS 420 QSPQLYNQTS 430 NPPGSPTEEA 440 QPSTSTSTQA 450 PAASPTGVVP 460 GTKYAVPDTS 470 TYQYDESSGY 480 YYDPTTGLYY 490 DPNSQYYYNS 500 LTQQYLYWDG 510 EKETYVPAAE 520 SSSHQQSGLP 530 PAKEGKEKKE 540 KPKSKTAQQI 550 AKDMERWAKS 560 LNKQKENFKN 570 SFQPVNSLRE 580 EERRESAAAD 590 AGFALFEKKG 600 ALAERQQLIP 610 ELVRNGDEEN 620 PLKRGLVAAY 630 SGDSDNEEEL 640 VERLESEEEK 650 LADWKKMACL 660 LCRRQFPNKD 670 ALVRHQQLSD 680 LHKQNMDIYR 690 RSRLSEQELE 700 ALELREREMK 710 YRDRAAERRE 720 KYGIPEPPEP 730 KRKKQFDAGT 740 VNYEQPTKDG 750 IDHSNIGNKM 760 LQAMGWREGS 770 GLGRKCQGIT 780 APIEAQVRLK 790 GAGLGAKGSA 800 YGLSGADSYK 810 DAVRKAMFAR FTEME

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005681 spliceosomal complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0000381 regulation of alternative mRNA splicing, via spliceosome
Biological Process GO:0006396 RNA processing
Biological Process GO:0000245 spliceosomal complex assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.