Search Results
Overview
| Uniprot ID | P52759 |
|---|---|
| Protein Name | 2-iminobutanoate/2-iminopropanoate deaminase |
| Gene Name | Rida |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 117 | YQVAALPKGSRIEIE |
Function
Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0120242 | 2-iminobutanoate deaminase activity |
| Molecular Function | GO:0120243 | 2-iminopropanoate deaminase activity |
| Molecular Function | GO:0043169 | cation binding |
| Molecular Function | GO:0019239 | deaminase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0036041 | long-chain fatty acid binding |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0016892 | RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism |
| Molecular Function | GO:0046914 | transition metal ion binding |
| Biological Process | GO:0070314 | G1 to G0 transition |
| Biological Process | GO:0001822 | kidney development |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0006402 | mRNA catabolic process |
| Biological Process | GO:0061157 | mRNA destabilization |
| Biological Process | GO:0050680 | negative regulation of epithelial cell proliferation |
| Biological Process | GO:0017148 | negative regulation of translation |
| Biological Process | GO:0033993 | response to lipid |
| Biological Process | GO:1902074 | response to salt |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.