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Overview

Uniprot IDP52789
Protein NameHexokinase-2
Gene NameHK2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
346 ISDIEGEKDGIRKAR
525 ATPDGTEKGDFLALD
549 LVRVRNGKWGGVEMH

Function

Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175)

Protein Sequence

10 MIASHLLAYF 20 FTELNHDQVQ 30 KVDQYLYHMR 40 LSDETLLEIS 50 KRFRKEMEKG 60 LGATTHPTAA 70 VKMLPTFVRS 80 TPDGTEHGEF 90 LALDLGGTNF 100 RVLWVKVTDN 110 GLQKVEMENQ 120 IYAIPEDIMR 130 GSGTQLFDHI 140 AECLANFMDK 150 LQIKDKKLPL 160 GFTFSFPCHQ 170 TKLDESFLVS 180 WTKGFKSSGV 190 EGRDVVALIR 200 KAIQRRGDFD 210 IDIVAVVNDT 220 VGTMMTCGYD 230 DHNCEIGLIV 240 GTGSNACYME 250 EMRHIDMVEG 260 DEGRMCINME 270 WGAFGDDGSL 280 NDIRTEFDQE 290 IDMGSLNPGK 300 QLFEKMISGM 310 YMGELVRLIL 320 VKMAKEELLF 330 GGKLSPELLN 340 TGRFETKDIS 350 DIEGEKDGIR 360 KAREVLMRLG 370 LDPTQEDCVA 380 THRICQIVST 390 RSASLCAATL 400 AAVLQRIKEN 410 KGEERLRSTI 420 GVDGSVYKKH 430 PHFAKRLHKT 440 VRRLVPGCDV 450 RFLRSEDGSG 460 KGAAMVTAVA 470 YRLADQHRAR 480 QKTLEHLQLS 490 HDQLLEVKRR 500 MKVEMERGLS 510 KETHASAPVK 520 MLPTYVCATP 530 DGTEKGDFLA 540 LDLGGTNFRV 550 LLVRVRNGKW 560 GGVEMHNKIY 570 AIPQEVMHGT 580 GDELFDHIVQ 590 CIADFLEYMG 600 MKGVSLPLGF 610 TFSFPCQQNS 620 LDESILLKWT 630 KGFKASGCEG 640 EDVVTLLKEA 650 IHRREEFDLD 660 VVAVVNDTVG 670 TMMTCGFEDP 680 HCEVGLIVGT 690 GSNACYMEEM 700 RNVELVEGEE 710 GRMCVNMEWG 720 AFGDNGCLDD 730 FRTEFDVAVD 740 ELSLNPGKQR 750 FEKMISGMYL 760 GEIVRNILID 770 FTKRGLLFRG 780 RISERLKTRG 790 IFETKFLSQI 800 ESDCLALLQV 810 RAILQHLGLE 820 STCDDSIIVK 830 EVCTVVARRA 840 AQLCGAGMAA 850 VVDRIRENRG 860 LDALKVTVGV 870 DGTLYKLHPH 880 FAKVMHETVK 890 DLAPKCDVSF 900 LQSEDGSGKG 910 AALITAVACR IREAGQR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0016529 sarcoplasmic reticulum
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005536 D-glucose binding
Molecular Function GO:0008865 fructokinase activity
Molecular Function GO:0004340 glucokinase activity
Molecular Function GO:0004396 hexokinase activity
Biological Process GO:0008637 apoptotic mitochondrial changes
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0072655 establishment of protein localization to mitochondrion
Biological Process GO:0006002 fructose 6-phosphate metabolic process
Biological Process GO:0051156 glucose 6-phosphate metabolic process
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0006096 glycolytic process
Biological Process GO:0001678 intracellular glucose homeostasis
Biological Process GO:0007595 lactation
Biological Process GO:0072656 maintenance of protein location in mitochondrion
Biological Process GO:0035795 negative regulation of mitochondrial membrane permeability
Biological Process GO:2000378 negative regulation of reactive oxygen species metabolic process
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:1905091 positive regulation of type 2 mitophagy
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0002931 response to ischemia

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.