Search Results
Overview
| Uniprot ID | P52815 |
|---|---|
| Protein Name | Large ribosomal subunit protein bL12m |
| Gene Name | MRPL12 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 142 | TEAKPVDKVKLIKEI |
| 150 | VKLIKEIKNYIQGIN |
| 162 | GINLVQAKKLVESLP |
| 163 | INLVQAKKLVESLPQ |
Function
As a component of the mitochondrial large ribosomal subunit, plays a role in mitochondrial translation (PubMed:23603806). When present in mitochondria as a free protein not associated with the ribosome, associates with mitochondrial RNA polymerase POLRMT to activate transcription (PubMed:22003127). Required for POLRMT stability (PubMed:26586915)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Molecular Function | GO:0003735 | structural constituent of ribosome |
| Biological Process | GO:0006390 | mitochondrial transcription |
| Biological Process | GO:0032543 | mitochondrial translation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0006412 | translation |
| Cellular Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0003723 | RNA binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.