Search Results

Overview

Uniprot IDP52825
Protein NameCarnitine O-palmitoyltransferase 2, mitochondrial
Gene NameCpt2
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
104 AHLLAQDKQNKHTSY
239 DELFTDTKARHLLVL
305 VWAELRQKLIHGGNE
424 FKLSSALKAGVTAAK
510 RPASIFTKRCSEAFV
544 KYHGQLTKEAAMGQG
56 LPRLPIPKLEDTMKR
69 KRYLSAQKPLLNDSQ
79 LNDSQFRKTEVLCKD
85 RKTEVLCKDFENGIG

Function

Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters

Protein Sequence

10 MMPRLLLRDW 20 PRCPSLVLGA 30 PSRPLSAVSG 40 PAEYLQHSIV 50 PTMHYQDSLP 60 RLPIPKLEDT 70 MKRYLSAQKP 80 LLNDSQFRKT 90 EVLCKDFENG 100 IGKELHAHLL 110 AQDKQNKHTS 120 YISGPWFDMY 130 LTARDSVVLN 140 FNPFMAFNPD 150 PKSEYNDQLT 160 RATNLTVSAV 170 RFLKTLRAGL 180 LEPEVFHLNP 190 ARSDTDAFKR 200 LIRFVPSSLS 210 WYGAYLVNAY 220 PLDMSQYFRL 230 FNSTRIPKPS 240 RDELFTDTKA 250 RHLLVLRKGH 260 FYVFDVLDQD 270 GNIVNPSEIQ 280 AHLKYILSDS 290 SPVPEFPLAY 300 LTSENRDVWA 310 ELRQKLIHGG 320 NEETLRKVDS 330 AVFCLCLDDF 340 PMKDLVHLSH 350 TMLHGDGTNR 360 WFDKSFNLIV 370 AKDGTAAVHF 380 EHAWGDGVAV 390 LRFFNEVFRD 400 STQTPAIAPQ 410 SQPAATDSSV 420 SVQKLSFKLS 430 SALKAGVTAA 440 KEKFDATMKT 450 LTIDAIQFQR 460 GGKEFLKKKK 470 LSPDAVAQLA 480 FQMAFLRQYG 490 QTVATYESCS 500 TAAFKHGRTE 510 TIRPASIFTK 520 RCSEAFVREP 530 SKHSVGELQH 540 MMAECSKYHG 550 QLTKEAAMGQ 560 GFDRHLFALR 570 YLAAARGVTL 580 PELYQDPAYQ 590 RINHNILSTS 600 TLSSPAVSLG 610 GFAPVVPDGF 620 GIAYAVHDDW 630 IGCNVSSYSG 640 RNAREFLHCV 650 QKCLEDMFDA LEGKAIKT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0016746 acyltransferase activity
Molecular Function GO:0008458 carnitine O-octanoyltransferase activity
Molecular Function GO:0004095 carnitine O-palmitoyltransferase activity
Biological Process GO:0009437 carnitine metabolic process
Biological Process GO:0006853 carnitine shuttle
Biological Process GO:0006635 fatty acid beta-oxidation
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0001676 long-chain fatty acid metabolic process
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.