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Overview

Uniprot IDP52873
Protein NamePyruvate carboxylase, mitochondrial
Gene NamePc
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1090 QLRSILVKDTQAMKE
1109 PKALKDVKGQIGAPM
1124 PGKVIDVKVAAGAKV
434 VKVIAHGKDHPTAAT
748 KDMAGLLKPAACTML
992 LNLKELEKDLIDRHG

Function

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate

Protein Sequence

10 MLKFQTVRGG 20 LRLLGVRRSS 30 TAPVASPNVR 40 RLEYKPIKKV 50 MVANRGEIAI 60 RVFRACTELG 70 IRTVAVYSEQ 80 DTGQMHRQKA 90 DEAYLIGRGL 100 APVQAYLHIP 110 DIIKVAKENG 120 VDAVHPGYGF 130 LSERADFAQA 140 CQDAGVRFIG 150 PSPEVVRKMG 160 DKVEARAIAI 170 AAGVPVVPGT 180 NSPINSLHEA 190 HEFSNTYGFP 200 IIFKAAYGGG 210 GRGMRVVHSY 220 EELEENYTRA 230 YSEALAAFGN 240 GALFVEKFIE 250 KPRHIEVQIL 260 GDQYGNILHL 270 YERDCSIQRR 280 HQKVVEIAPA 290 THLDPQLRSR 300 LTSDSVKLAK 310 QVGYENAGTV 320 EFLVDKHGKH 330 YFIEVNSRLQ 340 VEHTVTEEIT 350 DVDLVHAQIH 360 VSEGRSLPDL 370 GLRQENIRIN 380 GCAIQCRVTT 390 EDPARSFQPD 400 TGRIEVFRSG 410 EGMGIRLDNA 420 SAFQGAVISP 430 HYDSLLVKVI 440 AHGKDHPTAA 450 TKMSRALAEF 460 RVRGVKTNIP 470 FLQNVLNNQQ 480 FLAGIVDTQF 490 IDENPELFQL 500 RPAQNRAQKL 510 LHYLGHVMVN 520 GPTTPIPVKV 530 SPSPVDPIVP 540 VVPIGPPPAG 550 FRDILLREGP 560 EGFARAVRNH 570 QGLLLMDTTF 580 RDAHQSLLAT 590 RVRTHDLKKI 600 APYVAHNFNN 610 LFSIENWGGA 620 TFDVAMRFLY 630 ECPWRRLQEL 640 RELIPNIPFQ 650 MLLRGANAVG 660 YTNYPDNVVF 670 KFCEVAKENG 680 MDVFRIFDSL 690 NYLPNMLLGM 700 EAAGSAGGVV 710 EAAISYTGDV 720 ADPSRTKYSL 730 EYYMGLAEEL 740 VRAGTHILCI 750 KDMAGLLKPA 760 ACTMLVSSLR 770 DRFPDLPLHI 780 HTHDTSGSGV 790 AAMLACAQAG 800 ADVVDVAVDS 810 MSGMTSQPSM 820 GALVACTKGT 830 PLDTEVPLER 840 VFDYSEYWEG 850 ARGLYAAFDC 860 TATMKSGNSD 870 VYENEIPGGQ 880 YTNLHFQAHS 890 MGLGSKFKEV 900 KKAYVEANQM 910 LGDLIKVTPS 920 SKIVGDLAQF 930 MVQNGLSRAE 940 AEAQAEELSF 950 PRSVVEFLQG 960 YIGIPHGGFP 970 EPFRSKVLKD 980 LPRIEGRPGA 990 SLPPLNLKEL 1000 EKDLIDRHGE 1010 EVTPEDVLSA 1020 AMYPDVFAQF 1030 KDFTATFGPL 1040 DSLNTRLFLQ 1050 GPKIAEEFEV 1060 ELERGKTLHI 1070 KALAVSDLNR 1080 AGQRQVFFEL 1090 NGQLRSILVK 1100 DTQAMKEMHF 1110 HPKALKDVKG 1120 QIGAPMPGKV 1130 IDVKVAAGAK 1140 VVKGQPLCVL 1150 SAMKMETVVT 1160 SPMEGTIRKV 1170 HVTKDMTLEG DDLILEIE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004736 pyruvate carboxylase activity
Biological Process GO:0019752 carboxylic acid metabolic process
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0044794 host-mediated activation of viral process
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0019674 NAD+ metabolic process
Biological Process GO:0006739 NADP+ metabolic process
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0071073 positive regulation of phospholipid biosynthetic process
Biological Process GO:0019076 viral release from host cell
Biological Process GO:0019074 viral RNA genome packaging
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0009374 biotin binding

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.