Search Results

Overview

Uniprot IDP52888
Protein NameThimet oligopeptidase
Gene NameTHOP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
249 EAFNCRCKEENCAIL

Function

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:17251185, PubMed:7639763). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:17251185, PubMed:7639763). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity)

Protein Sequence

10 MKPPAACAGD 20 MADAASPCSV 30 VNDLRWDLSA 40 QQIEERTREL 50 IEQTKRVYDQ 60 VGTQEFEDVS 70 YESTLKALAD 80 VEVTYTVQRN 90 ILDFPQHVSP 100 SKDIRTASTE 110 ADKKLSEFDV 120 EMSMREDVYQ 130 RIVWLQEKVQ 140 KDSLRPEAAR 150 YLERLIKLGR 160 RNGLHLPRET 170 QENIKRIKKK 180 LSLLCIDFNK 190 NLNEDTTFLP 200 FTLQELGGLP 210 EDFLNSLEKM 220 EDGKLKVTLK 230 YPHYFPLLKK 240 CHVPETRRKV 250 EEAFNCRCKE 260 ENCAILKELV 270 TLRAQKSRLL 280 GFHTHADYVL 290 EMNMAKTSQT 300 VATFLDELAQ 310 KLKPLGEQER 320 AVILELKRAE 330 CERRGLPFDG 340 RIRAWDMRYY 350 MNQVEETRYC 360 VDQNLLKEYF 370 PVQVVTHGLL 380 GIYQELLGLA 390 FHHEEGASAW 400 HEDVRLYTAR 410 DAASGEVVGK 420 FYLDLYPREG 430 KYGHAACFGL 440 QPGCLRQDGS 450 RQIAIAAMVA 460 NFTKPTADAP 470 SLLQHDEVET 480 YFHEFGHVMH 490 QLCSQAEFAM 500 FSGTHVERDF 510 VEAPSQMLEN 520 WVWEQEPLLR 530 MSRHYRTGSA 540 VPRELLEKLI 550 ESRQANTGLF 560 NLRQIVLAKV 570 DQALHTQTDA 580 DPAEEYARLC 590 QEILGVPATP 600 GTNMPATFGH 610 LAGGYDAQYY 620 GYLWSEVYSM 630 DMFHTRFKQE 640 GVLNSKVGMD 650 YRSCILRPGG 660 SEDASAMLRR 670 FLGRDPKQDA 680 FLLSKGLQVG GCEPEPQVC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005758 mitochondrial intermembrane space
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004222 metalloendopeptidase activity
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0006508 proteolysis

Reference

[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.