Search Results
Overview
| Uniprot ID | P52926 |
|---|---|
| Protein Name | High mobility group protein HMGI-C |
| Gene Name | HMGA2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 26 | PAAPAPQKRGRGRPR |
| 34 | RGRGRPRKQQQEPTG |
| 74 | KAEATGEKRPRGRPR |
| 82 | RPRGRPRKWPQQVVQ |
Function
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236)
Protein Sequence
10
MSARGEGAGQ
20
PSTSAQGQPA
30
APAPQKRGRG
40
RPRKQQQEPT
50
GEPSPKRPRG
60
RPKGSKNKSP
70
SKAAQKKAEA
80
TGEKRPRGRP
90
RKWPQQVVQK
100
KPAQEETEET
SSQESAEED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0035497 | cAMP response element binding |
| Cellular Component | GO:0000228 | nuclear chromosome |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032993 | protein-DNA complex |
| Cellular Component | GO:0035985 | senescence-associated heterochromatin focus |
| Cellular Component | GO:0071141 | SMAD protein complex |
| Molecular Function | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity |
| Molecular Function | GO:0070742 | C2H2 zinc finger domain binding |
| Molecular Function | GO:0008301 | DNA binding, bending |
| Molecular Function | GO:0003906 | DNA-(apurinic or apyrimidinic site) endonuclease activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0035501 | MH1 domain binding |
| Molecular Function | GO:0035500 | MH2 domain binding |
| Molecular Function | GO:0003680 | minor groove of adenine-thymine-rich DNA binding |
| Molecular Function | GO:0003676 | nucleic acid binding |
| Molecular Function | GO:0031492 | nucleosomal DNA binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0046332 | SMAD binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0006284 | base-excision repair |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0002062 | chondrocyte differentiation |
| Biological Process | GO:0035988 | chondrocyte proliferation |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0030261 | chromosome condensation |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0035987 | endodermal cell differentiation |
| Biological Process | GO:0001837 | epithelial to mesenchymal transition |
| Biological Process | GO:0045444 | fat cell differentiation |
| Biological Process | GO:0031507 | heterochromatin formation |
| Biological Process | GO:0043922 | host-mediated suppression of viral transcription |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0048762 | mesenchymal cell differentiation |
| Biological Process | GO:0048333 | mesodermal cell differentiation |
| Biological Process | GO:0003131 | mesodermal-endodermal cell signaling |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:2000773 | negative regulation of cellular senescence |
| Biological Process | GO:0043392 | negative regulation of DNA binding |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:2001033 | negative regulation of double-strand break repair via nonhomologous end joining |
| Biological Process | GO:0033144 | negative regulation of intracellular steroid hormone receptor signaling pathway |
| Biological Process | GO:0046426 | negative regulation of receptor signaling pathway via JAK-STAT |
| Biological Process | GO:0045869 | negative regulation of single stranded viral RNA replication via double stranded DNA intermediate |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0090402 | oncogene-induced cell senescence |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0071864 | positive regulation of cell proliferation in bone marrow |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| Biological Process | GO:2000648 | positive regulation of stem cell proliferation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0010564 | regulation of cell cycle process |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:2000036 | regulation of stem cell population maintenance |
| Biological Process | GO:0009615 | response to virus |
| Biological Process | GO:0048863 | stem cell differentiation |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.