Search Results

Overview

Uniprot IDP52943
Protein NameCysteine-rich protein 2
Gene NameCRIP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
108 RKASGPPKGPSRASS
132 TCPRCSKKVYFAEKV
138 KKVYFAEKVTSLGKD
144 EKVTSLGKDWHRPCL
176 DGQPYCHKPCYGILF
205 YDRDPEGKVQP****
23 EKVSSLGKDWHKFCL
27 SLGKDWHKFCLKCER
55 DGKPFCHKPCYATLF

Function

No function data available.

Protein Sequence

10 MASKCPKCDK 20 TVYFAEKVSS 30 LGKDWHKFCL 40 KCERCSKTLT 50 PGGHAEHDGK 60 PFCHKPCYAT 70 LFGPKGVNIG 80 GAGSYIYEKP 90 LAEGPQVTGP 100 IEVPAARAEE 110 RKASGPPKGP 120 SRASSVTTFT 130 GEPNTCPRCS 140 KKVYFAEKVT 150 SLGKDWHRPC 160 LRCERCGKTL 170 TPGGHAEHDG 180 QPYCHKPCYG 190 ILFGPKGVNT 200 GAVGSYIYDR DPEGKVQP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Molecular Function GO:0008270 zinc ion binding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.