Search Results
Overview
| Uniprot ID | P52944 |
|---|---|
| Protein Name | PDZ and LIM domain protein 1 |
| Gene Name | Pdlim1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | EGKRHPYKMNLASEP |
| 196 | DKESEVYKMLQEKQE |
| 22 | GFRLVGGKDFEQPLA |
| 239 | PSGFRSVKAPVTKVA |
| 244 | SVKAPVTKVAASVGN |
| 254 | ASVGNAQKLPICDKC |
| 260 | QKLPICDKCGTGIVG |
| 87 | TVSRSEQKIWSPLVT |
| 98 | PLVTEEGKRHPYKMN |
Function
Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (By similarity). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (PubMed:22659164)
Protein Sequence
10
MTTQQIVLQG
20
PGPWGFRLVG
30
GKDFEQPLAI
40
SRVTPGSKAA
50
IANLCIGDLI
60
TAIDGEDTSS
70
MTHLEAQNKI
80
KGCVDNMTLT
90
VSRSEQKIWS
100
PLVTEEGKRH
110
PYKMNLASEP
120
QEVLHIGSAH
130
NRSAMPFTAS
140
PAPGTRVITN
150
QYNSPTGLYS
160
SENISNFNNA
170
VESKTSASGE
180
EANSRPSAQP
190
HPSGGLIIDK
200
ESEVYKMLQE
210
KQELNEPPKQ
220
STSFLVLQEI
230
LESDGKGDPN
240
KPSGFRSVKA
250
PVTKVAASVG
260
NAQKLPICDK
270
CGTGIVGVFV
280
KLRDHHRHPE
290
CYVCTDCGIN
300
LKQKGHFFVG
310
DQIYCEKHAR
320
ERVTPPEGYD
VVTVFPK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0031941 | filamentous actin |
| Cellular Component | GO:0001725 | stress fiber |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0051371 | muscle alpha-actinin binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity |
| Biological Process | GO:0010761 | fibroblast migration |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0030011 | maintenance of cell polarity |
| Biological Process | GO:0061061 | muscle structure development |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0043149 | stress fiber assembly |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.