Search Results
Overview
| Uniprot ID | P53004 |
|---|---|
| Protein Name | Biliverdin reductase A |
| Gene Name | BLVRA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 269 | LLGQFSEKELAAEKK |
Function
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:7929092, PubMed:8424666, PubMed:8631357). NADPH, however, is the probable reactant in biological systems (PubMed:7929092)
Protein Sequence
10
MNAEPERKFG
20
VVVVGVGRAG
30
SVRMRDLRNP
40
HPSSAFLNLI
50
GFVSRRELGS
60
IDGVQQISLE
70
DALSSQEVEV
80
AYICSESSSH
90
EDYIRQFLNA
100
GKHVLVEYPM
110
TLSLAAAQEL
120
WELAEQKGKV
130
LHEEHVELLM
140
EEFAFLKKEV
150
VGKDLLKGSL
160
LFTAGPLEEE
170
RFGFPAFSGI
180
SRLTWLVSLF
190
GELSLVSATL
200
EERKEDQYMK
210
MTVCLETEKK
220
SPLSWIEEKG
230
PGLKRNRYLS
240
FHFKSGSLEN
250
VPNVGVNKNI
260
FLKDQNIFVQ
270
KLLGQFSEKE
280
LAAEKKRILH
290
CLGLAEEIQK
YCCSRK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0106276 | biliberdin reductase (NADH) activity |
| Molecular Function | GO:0106277 | biliverdin reductase (NADPH) activity |
| Molecular Function | GO:0004074 | biliverdin reductase [NAD(P)H] activity |
| Molecular Function | GO:0000166 | nucleotide binding |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0042167 | heme catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.