Overview
| Uniprot ID | P53007 |
|---|
| Protein Name | Tricarboxylate transport protein, mitochondrial |
|---|
| Gene Name | SLC25A1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 149 |
PMETIKVKFIHDQTS |
| 160 |
DQTSPNPKYRGFFHG |
| 178 |
IVREQGLKGTYQGLT |
| 190 |
GLTATVLKQGSNQAI |
| 255 |
MQGLEAHKYRNTWDC |
| 268 |
DCGLQILKKEGLKAF |
| 277 |
EGLKAFYKGTVPRLG |
| 97 |
LLYGSIPKAAVRFGM |
Function
Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate (PubMed:26870663, PubMed:29031613, PubMed:29238895, PubMed:39881208, PubMed:38937634). Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate (PubMed:29031613). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (PubMed:38937634). In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes (PubMed:29031613, PubMed:29238895, PubMed:39881208)
Protein Sequence
10
MPAPRAPRAL
20
AAAAPASGKA
30
KLTHPGKAIL
40
AGGLAGGIEI
50
CITFPTEYVK
60
TQLQLDERSH
70
PPRYRGIGDC
80
VRQTVRSHGV
90
LGLYRGLSSL
100
LYGSIPKAAV
110
RFGMFEFLSN
120
HMRDAQGRLD
130
STRGLLCGLG
140
AGVAEAVVVV
150
CPMETIKVKF
160
IHDQTSPNPK
170
YRGFFHGVRE
180
IVREQGLKGT
190
YQGLTATVLK
200
QGSNQAIRFF
210
VMTSLRNWYR
220
GDNPNKPMNP
230
LITGVFGAIA
240
GAASVFGNTP
250
LDVIKTRMQG
260
LEAHKYRNTW
270
DCGLQILKKE
280
GLKAFYKGTV
290
PRLGRVCLDV
300
AIVFVIYDEV
310
VKLLNKVWKT
D
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0015297 |
antiporter activity |
| Molecular Function |
GO:0071913 |
citrate secondary active transmembrane transporter activity |
| Molecular Function |
GO:0015137 |
citrate transmembrane transporter activity |
| Molecular Function |
GO:0015142 |
tricarboxylic acid transmembrane transporter activity |
| Biological Process |
GO:0006843 |
mitochondrial citrate transmembrane transport |
| Biological Process |
GO:0110076 |
negative regulation of ferroptosis |
| Biological Process |
GO:0015711 |
organic anion transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.