Overview
| Uniprot ID | P53042 |
|---|
| Protein Name | Serine/threonine-protein phosphatase 5 |
|---|
| Gene Name | Ppp5c |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 111 |
ASNMALGKFRAALRD |
Function
Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed:11523989, PubMed:12176367, PubMed:15546861, PubMed:16549782, PubMed:16892053). Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (By similarity). Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (By similarity). Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (By similarity). Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (By similarity). Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E (By similarity). May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels (By similarity). Dephosphorylates and may play a role in the regulation of TAU/MAPT (PubMed:15546861). Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 (PubMed:16549782). Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (By similarity)
Protein Sequence
10
MAMAEGERTE
20
CAEPPRDEPP
30
AEGTLKRAEE
40
LKTQANDYFK
50
AKDYENAIKF
60
YSQAIELNPS
70
NAIYYGNRSL
80
AYLRTECYGY
90
ALGDATRAIE
100
LDKKYIKGYY
110
RRAASNMALG
120
KFRAALRDYE
130
TVVKVKPNDK
140
DAKMKYQECS
150
KIVKQKAFER
160
AIAGDEHRRS
170
VVDSLDIESM
180
TIEDEYSGPK
190
LEDGKVTITF
200
MKDLMQWYKD
210
QKKLHRKCAY
220
QILVQVKEVL
230
CKLSTLVETT
240
LKETEKITVC
250
GDTHGQFYDL
260
LNIFELNGLP
270
SETNPYIFNG
280
DFVDRGSFSV
290
EVILTLFGFK
300
LLYPDHFHLL
310
RGNHETDNMN
320
QIYGFEGEVK
330
AKYTAQMYEL
340
FSEVFEWLPL
350
AQCINGKVLI
360
MHGGLFSEDG
370
VTLDDIRKIE
380
RNRQPPDSGP
390
MCDLLWSDPQ
400
PQNGRSVSKR
410
GVSCQFGPDV
420
TKAFLEENQL
430
DYIIRSHEVK
440
AEGYEVAHGG
450
RCVTVFSAPN
460
YCDQMGNKAS
470
YIHLQGSDLR
480
PQFHQFTAVP
490
HPNVKPMAYA
NTLLQLGMM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0043204 |
perikaryon |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0101031 |
protein folding chaperone complex |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:1990635 |
proximal dendrite |
| Molecular Function |
GO:0043531 |
ADP binding |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0001965 |
G-protein alpha-subunit binding |
| Molecular Function |
GO:0031072 |
heat shock protein binding |
| Molecular Function |
GO:0030544 |
Hsp70 protein binding |
| Molecular Function |
GO:0051879 |
Hsp90 protein binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Molecular Function |
GO:0031435 |
mitogen-activated protein kinase kinase kinase binding |
| Molecular Function |
GO:0016791 |
phosphatase activity |
| Molecular Function |
GO:0004721 |
phosphoprotein phosphatase activity |
| Molecular Function |
GO:0030291 |
protein serine/threonine kinase inhibitor activity |
| Molecular Function |
GO:0004722 |
protein serine/threonine phosphatase activity |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0071276 |
cellular response to cadmium ion |
| Biological Process |
GO:0070301 |
cellular response to hydrogen peroxide |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:0043409 |
negative regulation of MAPK cascade |
| Biological Process |
GO:0001933 |
negative regulation of protein phosphorylation |
| Biological Process |
GO:0070262 |
peptidyl-serine dephosphorylation |
| Biological Process |
GO:2000324 |
positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway |
| Biological Process |
GO:0006470 |
protein dephosphorylation |
| Biological Process |
GO:1904550 |
response to arachidonate |
| Biological Process |
GO:0010288 |
response to lead ion |
| Biological Process |
GO:0043278 |
response to morphine |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.