Search Results
Overview
| Uniprot ID | P53365 |
|---|---|
| Protein Name | Arfaptin-2 |
| Gene Name | ARFIP2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 108 | INTYKCTKQLLSERF |
Function
Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network (PubMed:26507660). May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660). Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site (PubMed:30917996, PubMed:31204568). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658)
Protein Sequence
10
MTDGILGKAA
20
TMEIPIHGNG
30
EARQLPEDDG
40
LEQDLQQVMV
50
SGPNLNETSI
60
VSGGYGGSGD
70
GLIPTGSGRH
80
PSHSTTPSGP
90
GDEVARGIAG
100
EKFDIVKKWG
110
INTYKCTKQL
120
LSERFGRGSR
130
TVDLELELQI
140
ELLRETKRKY
150
ESVLQLGRAL
160
TAHLYSLLQT
170
QHALGDAFAD
180
LSQKSPELQE
190
EFGYNAETQK
200
LLCKNGETLL
210
GAVNFFVSSI
220
NTLVTKTMED
230
TLMTVKQYEA
240
ARLEYDAYRT
250
DLEELSLGPR
260
DAGTRGRLES
270
AQATFQAHRD
280
KYEKLRGDVA
290
IKLKFLEENK
300
IKVMHKQLLL
310
FHNAVSAYFA
320
GNQKQLEQTL
330
QQFNIKLRPP
340
GAEKPSWLEE
Q
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0032588 | trans-Golgi network membrane |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0030742 | GTP-dependent protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0140090 | membrane curvature sensor activity |
| Molecular Function | GO:0070273 | phosphatidylinositol-4-phosphate binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0030032 | lamellipodium assembly |
| Biological Process | GO:0000423 | mitophagy |
| Biological Process | GO:0034497 | protein localization to phagophore assembly site |
| Biological Process | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation |
| Biological Process | GO:0031529 | ruffle organization |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
| Cellular Component | GO:0005737 | cytoplasm |
Reference
PMID: N/A