Search Results

Overview

Uniprot IDP53396
Protein NameATP-citrate synthase
Gene NameACLY
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1080 YLDQKRLKQGLYRHP
4 ****MSAKAISEQTG
468 ADEVAPAKKAKPAMP
469 DEVAPAKKAKPAMPQ
471 VAPAKKAKPAMPQDS
488 SPRSLQGKSTTLFSR
780 VAKNQALKEAGVFVP
978 MGIGHRVKSINNPDM
991 DMRVQILKDYVRQHF

Function

Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism

Protein Sequence

10 MSAKAISEQT 20 GKELLYKFIC 30 TTSAIQNRFK 40 YARVTPDTDW 50 ARLLQDHPWL 60 LSQNLVVKPD 70 QLIKRRGKLG 80 LVGVNLTLDG 90 VKSWLKPRLG 100 QEATVGKATG 110 FLKNFLIEPF 120 VPHSQAEEFY 130 VCIYATREGD 140 YVLFHHEGGV 150 DVGDVDAKAQ 160 KLLVGVDEKL 170 NPEDIKKHLL 180 VHAPEDKKEI 190 LASFISGLFN 200 FYEDLYFTYL 210 EINPLVVTKD 220 GVYVLDLAAK 230 VDATADYICK 240 VKWGDIEFPP 250 PFGREAYPEE 260 AYIADLDAKS 270 GASLKLTLLN 280 PKGRIWTMVA 290 GGGASVVYSD 300 TICDLGGVNE 310 LANYGEYSGA 320 PSEQQTYDYA 330 KTILSLMTRE 340 KHPDGKILII 350 GGSIANFTNV 360 AATFKGIVRA 370 IRDYQGPLKE 380 HEVTIFVRRG 390 GPNYQEGLRV 400 MGEVGKTTGI 410 PIHVFGTETH 420 MTAIVGMALG 430 HRPIPNQPPT 440 AAHTANFLLN 450 ASGSTSTPAP 460 SRTASFSESR 470 ADEVAPAKKA 480 KPAMPQDSVP 490 SPRSLQGKST 500 TLFSRHTKAI 510 VWGMQTRAVQ 520 GMLDFDYVCS 530 RDEPSVAAMV 540 YPFTGDHKQK 550 FYWGHKEILI 560 PVFKNMADAM 570 RKHPEVDVLI 580 NFASLRSAYD 590 STMETMNYAQ 600 IRTIAIIAEG 610 IPEALTRKLI 620 KKADQKGVTI 630 IGPATVGGIK 640 PGCFKIGNTG 650 GMLDNILASK 660 LYRPGSVAYV 670 SRSGGMSNEL 680 NNIISRTTDG 690 VYEGVAIGGD 700 RYPGSTFMDH 710 VLRYQDTPGV 720 KMIVVLGEIG 730 GTEEYKICRG 740 IKEGRLTKPI 750 VCWCIGTCAT 760 MFSSEVQFGH 770 AGACANQASE 780 TAVAKNQALK 790 EAGVFVPRSF 800 DELGEIIQSV 810 YEDLVANGVI 820 VPAQEVPPPT 830 VPMDYSWARE 840 LGLIRKPASF 850 MTSICDERGQ 860 ELIYAGMPIT 870 EVFKEEMGIG 880 GVLGLLWFQK 890 RLPKYSCQFI 900 EMCLMVTADH 910 GPAVSGAHNT 920 IICARAGKDL 930 VSSLTSGLLT 940 IGDRFGGALD 950 AAAKMFSKAF 960 DSGIIPMEFV 970 NKMKKEGKLI 980 MGIGHRVKSI 990 NNPDMRVQIL 1000 KDYVRQHFPA 1010 TPLLDYALEV 1020 EKITTSKKPN 1030 LILNVDGLIG 1040 VAFVDMLRNC 1050 GSFTREEADE 1060 YIDIGALNGI 1070 FVLGRSMGFI 1080 GHYLDQKRLK 1090 QGLYRHPWDD 1100 ISYVLPEHMS M

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0016020 membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0003878 ATP citrate synthase activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0006085 acetyl-CoA biosynthetic process
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0006101 citrate metabolic process
Biological Process GO:0015936 coenzyme A metabolic process
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0008610 lipid biosynthetic process
Biological Process GO:0110076 negative regulation of ferroptosis
Biological Process GO:0006107 oxaloacetate metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.