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Overview

Uniprot IDP53534
Protein NameGlycogen phosphorylase, brain form
Gene NamePygb
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
254 AKAPNDFKLKDFNVG
3 *****MAKPLTDSER
316 IRRFKSSKFGCRDPV
42 HLHFTLVKDRNVATP
545 VKQENKLKFSAQLEK
552 KFSAQLEKEYKVKIN
609 RTVMIGGKAAPGYHM
811 RNIACSGKFSSDRTI

Function

Glycogen phosphorylase that regulates glycogen mobilization (By similarity). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

Protein Sequence

10 MAKPLTDSER 20 QKQISVRGIA 30 GLGDVAEVRK 40 SFNRHLHFTL 50 VKDRNVATPR 60 DYFFALAHTV 70 RDHLVGRWIR 80 TQQHYYERDP 90 KRIYYLSLEF 100 YMGRTLQNTM 110 VNLGLQTACD 120 EATYQLGLDL 130 EELEEIEEDA 140 GLGNGGLGRL 150 AACFLDSMAT 160 LGLAAYGYGI 170 RYEFGIFNQK 180 IVNGWQVEEA 190 DDWLRYGNPW 200 EKARPEYMLP 210 VHFYGRVEHT 220 PNGVLWLDTQ 230 VVLAMPYDTP 240 VPGYKNNTVN 250 TMRLWSAKAP 260 NDFKLKDFNV 270 GDYIEAVLDR 280 NLAENISRVL 290 YPNDNFFEGK 300 ELRLKQEYFV 310 VAATLQDIIR 320 RFKSSKFGCR 330 DPVRTCFETF 340 PDKVAIQLND 350 THPALSIPEL 360 MRILVDVEKV 370 DWDKAWEITK 380 KTCAYTNHTV 390 LPEALERWPV 400 SMFEKLLPRH 410 LEIIYAINQR 420 HLDHVAALFP 430 GDVDRLRRMS 440 VIEEGDCKRI 450 NMAHLCVIGS 460 HAVNGVARIH 470 SEIVKQSVFK 480 DFYELEPEKF 490 QNKTNGITPR 500 RWLLLCNPGL 510 AEIIVERIGE 520 GFLTDLSQLK 530 KLLSLVDDEA 540 FIRDVAKVKQ 550 ENKLKFSAQL 560 EKEYKVKINP 570 CSMFDVHVKR 580 IHEYKRQLLN 590 CLHIITLYNR 600 IKKDPTKTFV 610 PRTVMIGGKA 620 APGYHMAKMI 630 IKLVTSIGDV 640 VNHDPVVGDR 650 LRVIFLENYR 660 VSLAEKVIPA 670 ADLSQQISTA 680 GTEASGTGNM 690 KFMLNGALTI 700 GTMDGANVEM 710 AEEAGEENLF 720 IFGMRVEDVE 730 ALDQKGYNAQ 740 EFYERLPELR 750 QAVDQISSGF 760 FSPKDPDCFK 770 DVVNMLMYHD 780 RFKVFADYEA 790 YIQCQAQVDH 800 LYRNPKDWTK 810 KVIRNIACSG 820 KFSSDRTITE 830 YAREIWGVEP SDLQIPPP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0008184 glycogen phosphorylase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0030170 pyridoxal phosphate binding
Biological Process GO:0005980 glycogen catabolic process
Biological Process GO:0005977 glycogen metabolic process

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.