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Overview

Uniprot IDP53565
Protein NameHomeobox protein cut-like 1
Gene NameCux1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1479 DNPVRKKKAANLNSI

Function

Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator

Protein Sequence

10 MAANVGSMFQ 20 YWKRFDLQQL 30 QRELDATATV 40 LANRQDESEQ 50 SRKRLIEQSR 60 EFKKNTPEDL 70 RKQVAPLLKS 80 FQGEIDALSK 90 RSKEAEAAFL 100 TVYKRLIDVP 110 DPVPALDLGQ 120 QLEIKVQRLH 130 DIETENQKLR 140 ETLEEYNKEF 150 AEVKNQEVTI 160 KALKEKIREY 170 EQTLKSQAET 180 IALEKEQKLQ 190 NDFAEKERKL 200 QETQMSTTSK 210 LEEAEHKLQT 220 LQTALEKTRT 230 ELFDLKTKYD 240 EETTAKADEI 250 EMIMTDLERA 260 NQRAEVAQRE 270 AETLREQLSS 280 ANHSLQLASQ 290 IQKAPDVAIE 300 VLTRSSLEVE 310 LAAKEREIAQ 320 LVEDVQRLQA 330 SLTKLRENSA 340 SQISQLEQQL 350 NAKNSTLKQL 360 EEKLKGQADY 370 EDVKKELTTL 380 KSMEFAPSEG 390 AGTQDSTKPL 400 EVLLLEKNRS 410 LQSENATLRI 420 SNSDLSGSAR 430 RKGRDQPESR 440 RPGPLPASPP 450 PQLPRNTGEQ 460 VSNTNGTHHF 470 SPAGLSQDFF 480 SSNLASPSLP 490 LASTGKFALN 500 SLLQRQLMQS 510 FYSKAMQEAG 520 STSTIFSTGP 530 YSTNSISSPS 540 PLQQSPDVNG 550 MAPSPSQSES 560 AGSISEGEEI 570 DTAEIARQVK 580 EQLIKHNIGQ 590 RIFGHYVLGL 600 SQGSVSEILA 610 RPKPWNKLTV 620 RGKEPFHKMK 630 QFLSDEQNIL 640 ALRSIQGRQR 650 GNITTRIRAS 660 ETGSDEAIKS 670 ILEQAKRELQ 680 VQKTAEPVQA 690 SSTASSGNSD 700 DAIRSILQQA 710 RREMEAQQAA 720 LDPALKPAPL 730 SQPDLTILNP 740 KLLSASPMST 750 VSTYPPLAIS 760 LKKTPAAPEA 770 STSALPSAPA 780 LKKEAQDAPT 790 LDPPGSADAT 800 PGVLRPVKNE 810 LVRGSTWKDP 820 WWNPVQPERR 830 NLTTSEETKA 840 DETNASGKEK 850 TGSSQPRAER 860 SQLQGPSATA 870 EYWKEWPNAE 880 SPYSQSSELS 890 LTGASRSETP 900 QNSPLPSSPI 910 VPMAKPAKPS 920 VPPLTPEQYE 930 VYMYQEVDTI 940 ELTRQVKEKL 950 AKNGICQRIF 960 GEKVLGLSQG 970 SVSDMLSRPK 980 PWSKLTQKGR 990 EPFIRMQLWL 1000 NGELGQGVLP 1010 VQGQQQGPVL 1020 HSVTSLQDPL 1030 QQGCVSSEST 1040 PKTSASCSPA 1050 PESPMSSSES 1060 VKSLTELVQQ 1070 PCPTIETSKE 1080 GKPPEPSDPP 1090 TSDSQPTTPL 1100 PLSGHSALSI 1110 QELVAMSPEL 1120 DTYGITKRVK 1130 EVLTDNNLGQ 1140 RLFGETILGL 1150 TQGSVSDLLA 1160 RPKPWHKLSL 1170 KGREPFVRMQ 1180 LWLNDPNNVE 1190 KLMDMKRMEK 1200 KAYMKRRHSS 1210 VSDSQPCEPP 1220 SVGIDYSQGA 1230 SPQPQHQLKK 1240 PRVVLAPEEK 1250 EALKRAYQQK 1260 PYPSPKTIEE 1270 LATQLNLKTS 1280 TVINWFHNYR 1290 SRIRRELFIE 1300 EIQAGSQGQA 1310 GASDSPSARS 1320 SRAAPSSEGD 1330 SCDGVEAADT 1340 EEPGGNIVAT 1350 KSQGGPAEVT 1360 AAPADREEAT 1370 QPAEKAKAQP 1380 LSSGTPGQDD 1390 GEDAGRSRPP 1400 PEGLADAPAP 1410 VPNLAAPAAG 1420 EDAATSATAP 1430 AMATEAPGAA 1440 RAGPAERSSA 1450 LPSTSAPANA 1460 PARRPSSLQS 1470 LFGLPEAAGA 1480 RDNPVRKKKA 1490 ANLNSIIHRL 1500 EKAASREEPI EWEF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0042491 inner ear auditory receptor cell differentiation
Biological Process GO:0001822 kidney development
Biological Process GO:0030324 lung development
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0050775 positive regulation of dendrite morphogenesis
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0000301 retrograde transport, vesicle recycling within Golgi

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.