Search Results
Overview
| Uniprot ID | P53582 |
|---|---|
| Protein Name | Methionine aminopeptidase 1 |
| Gene Name | METAP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 311 | PNVPHYAKNKAVGVM |
| 313 | VPHYAKNKAVGVMKS |
Function
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle
Protein Sequence
10
MAAVETRVCE
20
TDGCSSEAKL
30
QCPTCIKLGI
40
QGSYFCSQEC
50
FKGSWATHKL
60
LHKKAKDEKA
70
KREVSSWTVE
80
GDINTDPWAG
90
YRYTGKLRPH
100
YPLMPTRPVP
110
SYIQRPDYAD
120
HPLGMSESEQ
130
ALKGTSQIKL
140
LSSEDIEGMR
150
LVCRLAREVL
160
DVAAGMIKPG
170
VTTEEIDHAV
180
HLACIARNCY
190
PSPLNYYNFP
200
KSCCTSVNEV
210
ICHGIPDRRP
220
LQEGDIVNVD
230
ITLYRNGYHG
240
DLNETFFVGE
250
VDDGARKLVQ
260
TTYECLMQAI
270
DAVKPGVRYR
280
ELGNIIQKHA
290
QANGFSVVRS
300
YCGHGIHKLF
310
HTAPNVPHYA
320
KNKAVGVMKS
330
GHVFTIEPMI
340
CEGGWQDETW
350
PDGWTAVTRD
360
GKRSAQFEHT
370
LLVTDTGCEI
380
LTRRLDSARP
HFMSQF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004177 | aminopeptidase activity |
| Molecular Function | GO:0004239 | initiator methionyl aminopeptidase activity |
| Molecular Function | GO:0070006 | metalloaminopeptidase activity |
| Molecular Function | GO:0008235 | metalloexopeptidase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0070527 | platelet aggregation |
| Biological Process | GO:0051604 | protein maturation |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0006417 | regulation of translation |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.