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Overview

Uniprot IDP53590
Protein NameSuccinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
Gene NameSUCLG2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
102 GVFSSGLKGGVHLTK
109 KGGVHLTKDPEVVGQ
292 PIENEAAKYDLKYIG
79 AAKRLNAKEIVLKAQ
94 ILAGGRGKGVFSSGL

Function

GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:8401211, PubMed:27487822). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity). Also able to act as a GTP-specific itaconyl- and malyl-CoA synthetase (By similarity)

Protein Sequence

10 IPAAPVAAQA 20 RKLLRDLAFR 30 PPLLAARSQV 40 VQLTPRRWLN 50 LQEYQSKKLM 60 SDNGVKVQRF 70 FVADTANEAL 80 EAAKRLNAKE 90 IVLKAQILAG 100 GRGKGVFSSG 110 LKGGVHLTKD 120 PEVVGQLAKQ 130 MIGYNLATKQ 140 TPKEGVKVNK 150 VMVAEALDIS 160 RETYLAILMD 170 RSCNGPVLVG 180 SPQGGVDIEE 190 VAASNPELIF 200 KEQIDIIEGI 210 KDSQAQRMAE 220 NLGFLGPLQN 230 QAADQIKKLY 240 NLFLKIDATQ 250 VEVNPFGETP 260 EGQVVCFDAK 270 INFDDNAEFR 280 QKDIFAMDDK 290 SENEPIENEA 300 AKYDLKYIGL 310 DGNIACFVNG 320 AGLAMATCDI 330 IFLNGGKPAN 340 FLDLGGGVKE 350 SQVYQAFKLL 360 TADPKVEAIL 370 VNIFGGIVNC 380 AIIANGITKA 390 CRELELKVPL 400 VVRLEGTNVH 410 EAQNILTNSG 420 LPITSAVDLE 430 DAAKKAVASV TKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0042709 succinate-CoA ligase complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004776 succinate-CoA ligase (GDP-forming) activity
Biological Process GO:0006104 succinyl-CoA metabolic process
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.