Search Results

Overview

Uniprot IDP53597
Protein NameSuccinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Gene NameSUCLG1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
105 LPVFNTVKEAKEQTG
192 IMPGHIHKKGRIGIV
308 GAIIAGGKGGAKEKI
54 RQHLYVDKNTKIICQ
57 LYVDKNTKIICQGFT
66 ICQGFTGKQGTFHSQ
90 VGGTTPGKGGQTHLG

Function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:34492704, PubMed:40108300). The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits (By similarity). Also able to act as an itaconyl- and malyl-CoA synthetase (PubMed:40108300)

Protein Sequence

10 MTATLAAAAD 20 IATMVSGSSG 30 LAAARLLSRS 40 FLLPQNGIRH 50 CSYTASRQHL 60 YVDKNTKIIC 70 QGFTGKQGTF 80 HSQQALEYGT 90 KLVGGTTPGK 100 GGQTHLGLPV 110 FNTVKEAKEQ 120 TGATASVIYV 130 PPPFAAAAIN 140 EAIEAEIPLV 150 VCITEGIPQQ 160 DMVRVKHKLL 170 RQEKTRLIGP 180 NCPGVINPGE 190 CKIGIMPGHI 200 HKKGRIGIVS 210 RSGTLTYEAV 220 HQTTQVGLGQ 230 SLCVGIGGDP 240 FNGTDFIDCL 250 EIFLNDSATE 260 GIILIGEIGG 270 NAEENAAEFL 280 KQHNSGPNSK 290 PVVSFIAGLT 300 APPGRRMGHA 310 GAIIAGGKGG 320 AKEKISALQS 330 AGVVVSMSPA 340 QLGTTIYKEF EKRKML

Gene Ontology

Classification GO ID Description
Cellular Component GO:1902494 catalytic complex
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0009361 succinate-CoA ligase complex (ADP-forming)
Cellular Component GO:0045244 succinate-CoA ligase complex (GDP-forming)
Molecular Function GO:0050074 malate-CoA ligase activity
Molecular Function GO:0000166 nucleotide binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0004775 succinate-CoA ligase (ADP-forming) activity
Molecular Function GO:0004776 succinate-CoA ligase (GDP-forming) activity
Molecular Function GO:0004774 succinate-CoA ligase activity
Biological Process GO:0006108 malate metabolic process
Biological Process GO:1901289 succinyl-CoA catabolic process
Biological Process GO:0110052 toxic metabolite repair
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.