Search Results
Overview
| Uniprot ID | P53602 |
|---|---|
| Protein Name | Diphosphomevalonate decarboxylase |
| Gene Name | MVD |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 207 | LVVSAEKKLTGSTVG |
Function
Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis
Protein Sequence
10
MASEKPLAAV
20
TCTAPVNIAV
30
IKYWGKRDEE
40
LVLPINSSLS
50
VTLHQDQLKT
60
TTTAVISKDF
70
TEDRIWLNGR
80
EEDVGQPRLQ
90
ACLREIRCLA
100
RKRRNSRDGD
110
PLPSSLSCKV
120
HVASVNNFPT
130
AAGLASSAAG
140
YACLAYTLAR
150
VYGVESDLSE
160
VARRGSGSAC
170
RSLYGGFVEW
180
QMGEQADGKD
190
SIARQVAPES
200
HWPELRVLIL
210
VVSAEKKLTG
220
STVGMRASVE
230
TSPLLRFRAE
240
SVVPARMAEM
250
ARCIRERDFP
260
SFAQLTMKDS
270
NQFHATCLDT
280
FPPISYLNAI
290
SWRIIHLVHR
300
FNAHHGDTKV
310
AYTFDAGPNA
320
VIFTLDDTVA
330
EFVAAVWHGF
340
PPGSNGDTFL
350
KGLQVRPAPL
360
SAELQAALAM
370
EPTPGGVKYI
380
IVTQVGPGPQ
390
ILDDPCAHLL
400
GPDGLPKPAA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004163 | diphosphomevalonate decarboxylase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0033489 | cholesterol biosynthetic process via desmosterol |
| Biological Process | GO:0033490 | cholesterol biosynthetic process via lathosterol |
| Biological Process | GO:0010142 | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0033386 | geranylgeranyl diphosphate biosynthetic process |
| Biological Process | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0008299 | isoprenoid biosynthetic process |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0036197 | zymosterol biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.