Overview
| Uniprot ID | P53611 |
|---|
| Protein Name | Geranylgeranyl transferase type-2 subunit beta |
|---|
| Gene Name | RABGGTB |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 6 |
**MGTPQKDVIIKSD |
Function
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A (PubMed:7991565). Catalytic subunit of the geranylgeranyl transferase type 3 (GGTase-3) complex (PubMed:31209342, PubMed:32128853). The GGTase-3 complex geranylgeranylates and targets FBXL2 to the cellular membranes, where FBXL2 forms part of the E3 ubiquitin-protein ligase complex SCF(FBXL2) that mediates the degradation of membrane-anchored proteins (PubMed:31209342, PubMed:32128853). The GGTase-3 complex geranylgeranylates Golgi v-SNARE protein YKT6 at 'Cys-194' and this prenylation is required for Golgi SNARE complex assembly (PubMed:32128853)
Protein Sequence
10
MGTPQKDVII
20
KSDAPDTLLL
30
EKHADYIASY
40
GSKKDDYEYC
50
MSEYLRMSGI
60
YWGLTVMDLM
70
GQLHRMNREE
80
ILAFIKSCQH
90
ECGGISASIG
100
HDPHLLYTLS
110
AVQILTLYDS
120
INVIDVNKVV
130
EYVKGLQKED
140
GSFAGDIWGE
150
IDTRFSFCAV
160
ATLALLGKLD
170
AINVEKAIEF
180
VLSCMNFDGG
190
FGCRPGSESH
200
AGQIYCCTGF
210
LAITSQLHQV
220
NSDLLGWWLC
230
ERQLPSGGLN
240
GRPEKLPDVC
250
YSWWVLASLK
260
IIGRLHWIDR
270
EKLRNFILAC
280
QDEETGGFAD
290
RPGDMVDPFH
300
TLFGIAGLSL
310
LGEEQIKPVN
320
PVFCMPEEVL
330
QRVNVQPELV
S
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0005968 |
Rab-protein geranylgeranyltransferase complex |
| Molecular Function |
GO:0004663 |
Rab geranylgeranyltransferase activity |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006888 |
endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process |
GO:0018344 |
protein geranylgeranylation |
| Biological Process |
GO:0036211 |
protein modification process |
| Biological Process |
GO:0007601 |
visual perception |
Reference
PMID: N/A